Pharmazeutischer Zwischenrohstoff CAS 1421373-66-1 Osimertinib Mesylat Pulver

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Product origin: Xi'an, Shaanxi, China

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US$ 10 ~ 120

Description

Pharmaceutical Intermediate Raw Material CAS 1421373-66-1 Osimertinib Mesylate Powder

Specification of Analysis

Product Name	Osimertinib Mesylate Powder
CAS	1421373-66-1
Appearance	White to off-white powder
Molecular formula	C22H28N6O8
Molecular Weight	595.71
Assay	98%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

What is Osimertinib mesylate?

Osimertinib (previously known as mereletinib or AZD9291) is a third-generation epidermal g factor receptor tyrosine kinase inhibitor drug.

AZD9291 is a Kinase Inhibitor. The mechanism of action of osimertinib is as a Kinase Inhibitor, and Cytochrome P450 3A Inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor.

As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR.

Function

AZD9291 used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC). Osimertinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.

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