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High Purity 99% Quality Vitamin D Derivative CAS 32222-06-3 Calcitriol Raw Material Powder

High Purity 99% Quality Vitamin D Derivative CAS 32222-06-3 Calcitriol Raw Material Powder

Min.Order: 10
Product origin: Xi'an, Shaanxi, China
Infringement complaint: complaintComplaint
US$ 1 ~ 10

Description


What is Vitamin D Derivative Drugs?

Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.

Basic Information
 
Product Name:
Calcitriol
 
Synonyms:Calcitriol Impurity;
Vitamin D, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem;
(5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol;
1,25-dhcc;
1,25-dihydroxycholecalciferol;
1,25-dihydroxyvitamind;
1a,25-dihydroxy-cholecalcifero;
1-alpha,25-dihydroxy-cholecalcifero
CAS:32222-06-3
MF:C27H44O3
MW:416.64
EINECS:250-963-8
Product Categories:Miscellaneous Biochemicals;Vitamin D3 analogs;API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Isolabel;reagent;standard substance
Quality Standard:USP9.0
Molecular Structure:

Chemical Properties
 
Melting point 119-1210C
Alpha D25 +48° (methanol)
Boiling point 474.91°C (rough estimate)
Density 1.0362 (rough estimate)
Refractive index 1.4700 (estimate)
Fp 14 °C
Storage temp. 2-8°C
λmax265nm(lit.)
Merck 14,1644
BRN 7559394
Stability:Air and Light Sensitive

Uses

1)Calcium regulator, anti-psoriatic;

2)Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

3)The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

4)Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts. 
 
Packing & Shipment
 



Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process. 
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis. 
3) Procurement-Strictly on selecting raw materials. 
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards. 
5) Warehousing and storage: Clear and dry condition with suitable temperature. 
6) Transportation - Audit and supervise the logistics environment to ensure storage safety. 
7) Keep samples for all batches goods to be traceable in case of quality discrepance. 


Certification 



 
Q1: Which kind of payment terms do you accept? 
For small order, you can pay by T/T or Western Union, nomal order by T/T to our company account. 

Q2: Can you give me a discount price? 
Surely, It depend on your quantity. 

Q3: How can I get a sample? 
Free samples is available, but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders? 
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests. 

Q5: How do you treat quality complaint? 
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your
M. P. 
  
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