Complaint
Hormone High Quality Estrone/1,3,5(10)-Estratrien-3-ol-17-one Powder CAS. 53-16-7 99% Purity
| Product name | Estrone/1,3,5(10)-Estratrien-3-ol-17-one |
| CAS no. | 53-16-7 |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 |
| Brand Name | Senwayer |
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
a) Estrone is mainly as intermediate of Ethinyl Estradiol.
b) Estrone is one of Several Natural Estrogens, which also include estriol and estradiol. Estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.
Estrone was previously marketed in intramuscular and vaginal formulations and was used as an estrogen in the treatment of symptoms of hypoestrogenism such as hot flashes and atrophic vaginitis in menopausal or ovariectomized women. It has since been discontinued and is no longer available, having been superseded by other estrogens with greater potency and improved pharmacokinetics (namely oral bioavailability and duration). Although estrone itself is no longer used medically, other marketed estrogens such as estradiol and estrone sulfate produce estrone as a major metabolite.
