Complaint
Product Information
| Description | FOXO3A rabbit polyclonal |
| Protein full name | Forkhead box protein O3 |
Synonyms | FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse FOXO3A |
Isotype | IgG |
Purity | Affinity purification |
| Predicted MW. | 72/97KDa |
| Observed MW. | 72/97KDa |
Uniprot ID | Q9WVH4,O43524 |
Applications
| Applications | WB |
Species | Human, Rat, Mouse |
Dilution | 1:1000 |
Positive tissue | 293T, MCF7, liver cancer, glioma, lung, brain |
Images
Western blot analysis of FOXO3A (GB11092-1) at dilution of 1:1000. Lane 1: 293T cell lysate Lane 2: MCF7 cell lysate Lane 3: SH-SY5Y cell lysate Lane 4: Human liver cancer tissue lysate Lane 5: Human glioma tissue lysate Lane 6: Mouse lung tissue lysate Lane 7: Mouse brain tissue lysate Lane 8: Rat brain tissue lysate |
Background
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
