Complaint
Description:
CAS: 15687-27-1
MF: C13H18O2
MW: 206.28
Appearance:white crystalline powder
Purity:99% Min.
Standard:99% min.
Product Name: Ibuprofen
Synonyms: RARECHEM AL BO 0989;MOTRIN(TM);(+/-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID;2-(4-ISOBUTYLPHENYL)PROPIONIC ACID;4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID;AKOS NCG1-0060
CAS: 15687-27-1
MF: C13H18O2
MW: 206.28
EINECS: 239-784-6
Product Categories: Active Pharmaceutical Ingredients;API;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Lipid signaling;Isotopically Labeled Pharmaceutical Reference Standard;ADVIL;Other APIs
mp 77-78 °C(lit.)
bp 157 °C (4 mmHg)
storage temp. -20deg;C Freezer
Water Solubility insoluble
Merck 14,4881
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Chemical Properties : Colourless, Crystalline Solid
Application :
Indomethacin is commonly used as a prescription medication to treat fever, analgesic or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, rheumatism, or tendinitis.
Indometacin works by reducing the production of prostaglandins, Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Indometacin is similar to ibuprofen (Motrin) and naproxen (Naprosyn, Aleve).
Usage :
A selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency
antiinflammatory
Antibiotic
Anti-inflammatory, analgesic, antipyretic effect. The efficacy of the treatment of rheumatism and rheumatoid arthritis slightly inferior to acetyl salicylic acid and phenylbutazone. Suitable for the treatment of rheumatic arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis. The product in 1985 America drug sales order in thirteenth.
Product name | Ibuprofen | |||
| CAS No. | 15687-27-1 | Outer Packing | 20KG | |
| Production date | 2016.07.21 | Shelf life | 2018.06 | |
| Standard adopted | QJ/XP-03-06-032A(03) | |||
| Items of analysis | Specification | Results | ||
| Description | White crystalline powder, slightly smelly, almost no flavour | White crystalline powder, slightly smelly, almost no flavour | ||
| Ientification | UV conform | conform | ||
| Ientification | IR conform | conform | ||
| Cloride | ≤0.010% | <0.010% | ||
| Relative substance | Single largest impurity ≤0.05% | 0.01% | ||
| Relative substance | Total impurities≤0.30% | 0.03% | ||
| Ibuprofen related substances C | ≤0.1% | Not detected | ||
| Loss on drying | ≤0.5% | 0.04% | ||
| Burning residue | ≤0.1% | 0.05% | ||
| Heavy metals | ≤0.001% | <0.001% | ||
| Assay | ≥98.5% | 99.9% | ||
| Residual solvents | Ethanol≤0.05% | 0.0057% | ||
| Residual solvents | Dichloromethane ≤0.01% | Not detected | ||
| Conclusion | Qualified | |||
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