Bulk Local Anesthesia Drugs Tetracaine Hcl CAS 136-47-0 Powder For Paining Resist 

 

Tetracaine HCl Quick Detail:

Product Name	Tetracaine Hydrochloride,Tetracaine HCL
Alias	Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS NO	136-47-0
EINECS	205-248-5
Molecular Formula	C15H25ClN2O2
Molecular Weight	300.82
MS	99% USP 136-47-0 Tetracaine HCl/Tetracaine Hydrochloride
Melting Point	149° C
Assay	99%
Grade	Medicine Grade
Storage	Closed, confined and shading preservation
Usage	Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

 

Tetracaine HCl Description:

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
 
 
Tetracaine HCl Application:
Tetracaine hydrochloride (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
Tetracaine hydrochloride,In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Tetracaine HCl Usage:

Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum and Tetracaine hydrochloride is used for spinal anesthesia.

 

Tetracaine HCl COA :

 

Test Items	Specification	Test Results
Appearance	Fine, white, crystalline, odorless powder	confirm
Identification	ABC in Pass	confirm
Solubility	Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene	confirm
USP Reference standards	USP Tetracaine Hydrochloride RS. USP Endotoxin RS.	confirm
Melting point	145~150 degree	146.0~147.5 degree
Chromatographic purity	In Pass	confirm
Related substance	Not more than the reference solution 0.05%	confirm
Heavy metals	≤10ppm	confirm
PH	4.5-6.5	5.8
Residue on ignition	≤0.10%	0.05%
Loss on Drying	≤ 0.5%	0.19%
Assay	98.0 -101.0%	100.1%
Conclusion	Confirms USP 32

 

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Bulk Local Anesthesia Drugs Tetracaine Hcl CAS 136-47-0 Powder For Paining Resist