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Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as Procaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine was first synthesized in 1905, shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Procaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun. Prior to the discovery of amylocaine and procaine, was the most commonly used local anesthetic.[citation needed] Einhorn wished his new discovery to be used for amputations, but surgeons preferred general anesthetic. Dentists, however, found it very useful. Einhorn was displeased by this[why?] and spent many years touring dental schools to advise them not to use it.
Specification:
Test Items | Specification | Test Results |
Appearance | White crystals or a white crystalline powder | Conform |
Identification | A\B\E. It appears positive reaction | |
Melting point | 154degree~158degree | 154degree~157degree |
Acidity | PH 5.0~6.5 | PH=5.9 |
Appearance of solution | Clear and colourless | Conform |
Loss on drying | ≤0.5% | 0.07% |
Heavy metals | ≤0.0005% | Conform |
Related substances | ≤0.05% | Conform |
Sulphated ash | ≤0.1% | 0.05% |
Assay ( on dry basis ) | 99.0-101.0% | 99.87% |
Conclusion | Conform to BP2005 |
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Procaine is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
Procaineis used as an injection during surgery and other medical and dental procedures.
Procaine suggested for use in reversing aging in modern times, it could be used to combat arthritis, arteriosclerosis, senile skin changes and baldness. Procaine containing benzoic acid has beenshown to markedly improve the absorption of procaine by fats, thus quickening its absorption by the human body. Procaine also increases the speed with which the nerves conduct impulses, and decreases the rate of excretion of the 17 kerosteroids, which usually increases with age.
Procaine's anti-aging benefits include increased nerve velocities, improved sense of well-being and increased potential life span.