Complaint
Basic Info:
Model NO.: 68-35-9Sulfadiazine is an antibiotic. Used together with pyrimethamine, it is the treatment of choice for toxoplasmosis. It is a second line treatment for otitis media, prevention of rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. It is taken by mouth.
Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. It should not be used in people who have severe liver problems, kidney problems, or porphyria. If used during pregnancy it may increase the risk of kernicterus in the baby. While the company that makes it does not recommend use during breastfeeding, use is believed to be safe if the baby is otherwise healthy.It is in the sulfonamide class of medications.
Sulfadiazine was approved for medical use in the United States in 1941. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Sulfadiazine is available as a generic medication. The wholesale cost in the developing world is about 2.70 to 7.32 USD a month. In the United States treatment costs more than 200 USD a month.
The COA of Sulfadiazine:
| Product name | Sulfadiazine | |||
| CAS No. | 68-35-9 | Outer Packing | 25kg | |
| Production date | 2017.6.17 | Shelf life | 2019.6.16 | |
| Standard adopted | JPC | |||
| Items of analysis | Specification | Results | ||
| appearance | white or pale yellow crystalline power,and it is odorless and testeless | conform | ||
| solubility | it is freely slouble in pyridine,slightly soluble in acetone , very slightly soluble in ethanol, and practically insoluble in water an erher.it dissolves in dilute hydrochloric acid, sodium hydroxide TS and ammonia TS. | conform | ||
| identification(A) | the solution responds to Qualitative Tests for paimary aromatic amines | conform | ||
| identification(B) | the chloroform layer develops a pale-gree color | conform | ||
| identification(C) | the chloroform layer develops a gree color | conform | ||
| identification(D) IR | it exhibits at wave about 3440 cm-1,3360cm-1,3040cm-1,1652cm-1,1582cm-1,1494cm-1,1327cm-1,1158cm-1,797cm-1 | conform | ||
| melting point | about 252ºC | 256~228.4ºC | ||
| clarity and color of solution | the solution is clear and colorless to pale yellow | conform | ||
| acidity | a yellow color develops | conform | ||
| chloride | NMT 0.014% | conform | ||
| sulfate | NMT 0.038% | conform | ||
| heavy metals | NMT 20ppm | conform | ||
| arsenic | NMT 2ppm | conform | ||
| related substances | the spots other than the principal spot form the sample solution are not more intense than the spot form the standard solution. | conform | ||
| loss on drying | NMT 0.5% | 0.09% | ||
| residue on ignition | NMT 0.1% | 0.04% | ||
| assay | NLT 98.0% | 99.60% | ||
| Conclusion | Qualified | |||
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