[Indicationsl] Doxycycline is used for many different types of infections, including respiratory tract infections due to hemophilus influanzae. Streptococcis pneumoniae, or mycoplasma pneumoniae. It also is used for the treatment of nongonococcal urethritis(Due to Ureaplasma). Rocky mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, syphilis, and acne. [Dosage ] Adult: 100-200mg daily as a single dose or divided doses. Children:2-4mg/kg body weight daily in single or divided doses. It is not recomnended to the children not older than 8 years and women during pregnancy.
Doxycycline should be taken at least one hour before or two hours after meals because food binds doxycycline and prevents its absorption. For most infections, doxycycline taken once or twice daily for7 to 14 days. Sometimes, the first dose is given as a "double dose", that is, twice as large as the remainder of the doses.
[Drug Interactions]. It is recommended that doxycycline not be taken at the same time as aluminum-, magnesium-, or calcium-based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medicines bind doxycycline in the intestine. Similarly, doxycycline should not be taken with minerals(such as calcium or iron), with bismuth subsalicylate (Pepto Bismal) or with dairy products. Doxycycline may enhance the activity of warfarin and cause excessive . thinning" of the blood, necessitating a reduction in the dose of warfarin. Phenytoi, Carbamazepine, and Barbiturates may enhance the metabolism of doxycycline thus making it less effective. [Pregnancy] Tetracycline antibiotics, such as doxycycline , can have toxic effects on development of bone in the fetus. Therefore, tetracyclines are not recommended during pregnancy unless there is no other appropriate antibiotics. [Nursing mothers] Doxycycline is secreted into breast milk. Since tetracyclines can cause decreased bone, the use of tetracyclines in nursing mothers is of concern. The physician must decide whether to recommend that a nursing mother discontinue nursing during treatment with tetracyclines or to choose a different antibiotic. [Side-effects] Doxycycline is generally well-tolerated. The most common side effects are diarrhea or loose stools, nausea, abdominal pain, and vomiting. Tetracyclines, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age, exaggerated sunburn can occur with tetracyclines , therefore, sunlight should be minimized during treatment. [Packing] 10tablets in one blister, 10 blisters or 100 blisters in one box, or 1000 tablets in one jar. [Storage] Stored away from light, in a dry, cool place.
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