ISO Factory Supply Best Price Cyclosporine a 59865-13-3

Basic Information:
Product Name: Cyclosporine A
Synonyms Name: Cyclosporine      
CAS No.: 59865-13-3
Molecular Formula: C62H111N11O12

Product Description:
Cyclosporine or cyclosporine A, is an immunosuppressant drug. Cyclosporine widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Cyclosporine has been studied in transplants of skin, heart, kidney, liver, lung, pancreas, bone marrow, and small intestine. Cyclosporine initially isolated from the fungus Tolypocladium inflatum isolated from a soil, ciclosporine is a cyclicnonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.
Cyclosporine is thought to bind to the cytosolic protein cyclophilin(immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Ciclosporin prevents the dephosphorlyation of NF-AT by binding to cyclophilin.[7] It also inhibits lymphokine production andinterleukin release and, therefore, leads to a reduced function of effector T-cells. It does not affect cytostaticactivity.

Function:
It also has an effect on mitochondria. Ciclosporine prevents the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. However, this is not the primary mechanism of action for clinical use, but rather an important effect for research on apoptosis
1) It is an immunosuppressant drug.
2) Cyclosporin A is widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection.
 

FAQ

1:  How to start orders or make payments?

You can send your Purchase order, or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma
Invoice with our bank details for your confirmation, then you can make payment accordingly.

2:  How to make the payment?
We can accept L/C, T/T, West Union, Money Gram etc.

3: What's your MOQ?
For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts from 100g and 1kg.

4:  When will you deliver the goods?
If we have inventory, generally we can arrange shipment after receipt of payment 2 to 3 days. If not, it will be decided by the time of the factory production.


Our advantages
1.High quality with competitive price.
2. All purity>99%.
3. We are manufacturer and can provide high quality products with factory price.
Fast and safe delivery.

1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet  shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

We have clients throughout the world.
1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2. Market feedback and goods feedback will be appreciated , meeting customers' requirement is our responsibility.
3. High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
5.Sample order are welcome.
6.NMR,HPLC and COA can be supplied
7.We can supply sample for testing
8.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!