Complaint
MedKoo Cat#: 524609
Name: Cgp 11130
CAS#: 52237-19-1
Chemical Formula: C10H12FNO2
Exact Mass: 197.08521
Molecular Weight: 197.21
Elemental Analysis: C, 60.90; H, 6.13; F, 9.63; N, 7.10; O, 16.23
F-Phenibut (Fluorophenibut) is a several-fold more potent derivative of Phenibut. Phenibut is an atypical anxiolytic and nootropic compound structurally similar to the well known inhibitory neurotransmitter GABA, as well as to baclofen (β-(4-chlorophenyl)-GABA) and pregab (β-isobutyl-GABA)[1]. Phenibut was originally thought to act solely as a selective GABAB receptor agonist, similar to its much more potent relative baclofen, but has more recently been found to additionally act with somewhat higher affinity as an inhibitor of α2δ subunit-containing voltage-gated calcium channels, a mechanism of action shared with gabapentin and pregaba.[2]
Phenibut is known to have a wider spectrum of effects than baclofen; for example Phenibut has been found to be more effective as a nootropic and neuroprotective compound than baclofen[2],[3], while baclofen has a more narrowly focused spectrum of effects and anecdotally shows a reduced tendency to induce habituation or tolerance to its effects upon chronic daily administration[4].
Preliminary (unpublished) research tentatively suggests that F-Phenibut (Fluorophenibut) has a behavioral potency of approximately five to tenfold higher than Phenibut in vivo, with approximately sixfold higher affinity as a GABAB agonist than Phenibut[5], but may also retain comparable affinity and inhibitory efficacy at α2δ subunit-containing voltage-gated calcium channels, making F-Phenibut unique as an evenly balanced ligand for these two binding sites. As an intermediary between Phenibut and baclofen, these findings hint at the potential promise that this p-fluoro relative of Phenibut might retain the broader nootropic, anxiolytic, and mood elevating characteristics of Phenibut, while simultaneously partially sharing the relatively reduced tolerance inducing properties of its p-chloro relative baclofen.
Certificate Of Analysis
| CAS Number: | 52237-19-1 |
|---|---|
| Purity: | ≥98% |
| Molecular Weight: | 233.66 g/mol |
| Melting Point: | Unknown |
| Molecular Formula: | C10FH12NO2 •HCl |
| Synonyms: | 4-Amino-3-(4-fluorophenyl)butanoic acid hydrochloride, 4-Amino-3-(4-fluorophenyl)butyric acid, Fluorophenibut HCL, F-Phenibut, Fluoribut, Fenibut |
| PubChem CID: | 103611 |
| SMILES: | C1(F)=CC=C(C=C1)C(CC(=O)O)CN |
| Application: | F-Phenibut (Fluorophenibut) is a several-fold more potent derivative of the nootropic and anxiolytic gamma amino butyric acid derivative, Phenibut; useful as a GABAB and α2δ subunit-containing voltage-gated calcium channel ligand |
|---|---|
| Appearance: | White or off-white crystalline powder |
| Physical State: | Solid |
| Solubility: | Freely soluble in Ethanol, Water. |
| Storage: | Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity. |
| Stability: | Stable for at least two years when stored as above. |
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