Complaint
| Brief Introduction | |
| Name | Beta-Methyl Vinyl Phosphate |
| Synonyms | beta-Methyl vinyl phosphate MAP |
| (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate | |
| (1R,5S,6S)-2-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate | |
| (1R,5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-[(diphenylphosphono)-oxy]-1-methylcarbapen-2-em-3-carboxylic acid 4-nitrobenzyl ester | |
| [4R-[4α, 5β,6β(R*)]]-3-[(diphenoxyphosphinyl)oxy]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | |
| 4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | |
| CAS | 90776-59-3 |
| EINECS | 618-646-2 |
| Molecular Formula | C29H27N2O10P |
| Molecular Weight | 594.51 |
| Properties | |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Melting Point | 126-130ºC |
| Boling Point | 722.4±60.0 °C(Predicted) |
| Flash Point | 390.671°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White Powder |
| Color | White to Off-White |
| pKa | 14.36±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.653 |
| Usage | Used as a pharmaceutical intermediate, also can be used for the preparation of pivol ester of tibipenem. |
| Packing | 20kg/barrel(Lined with a plastic bag, sealed with an aluminum foil bag, and with a paper cylinder outside) |
| Specific spin | [α]D20 =+45°~+55° |
| PSA | 167.23 |
| LogP | 2.13 |
| Density | 1.5±0.1 g/cm3 |
| MDL Number | MFCD01318092 |
| InChI | InChI=1/C29H27N2O10P/c1-18-25-24(19(2)32)28(33)30(25)26(29(34)38-17-20-13-15-21(16-14-20)31(35)36)27(18)41-42(37,39-22-9-5-3-6-10-22)40-23-11-7-4-8-12-23/h3-16,18-19,24-25,32H,17H2,1-2H3/t18-,19-,24-,25-/m1/s1 |
Product Description
Beta-Methyl Vinyl Phosphate is a pharmaceutical intermediate that can be used to prepare tibipenem pivoxil. Tibipenem pivoxil, chemically known as (+) - (4R, 5S, 6S) - 6 - [(1R) - hydroxyethyl] - 4-methyl-7-oxo-3 [[1 - (2-thiazolin-2-yl) - 3-azacyclobutanyl] sulfur] - 1-azabicyclic [3.2.0] hept-2-en-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy) methyl ester, is a carbapenem antibiotic. After absorption in the intestinal tract, Tibipenem pivoxil is metabolized to Tibipenem, showing antibacterial activity.
Tibipenem has broad-spectrum antibacterial activity against gram-positive bacteria and gram-negative bacteria, including Staphylococcus, Streptococcus, Pneumococcus (including PRSP), and Moraxella catarrhalis (including β- Lactam producing bacteria), Haemophilus influenzae (including ampicillin resistant Haemophilus influenzae) have strong antibacterial activity. In particular, compared to previous oral antibiotics, tibpenem exhibits extremely strong antibacterial activity against pathogenic bacteria such as otitis media, paranasal sinusitis, and pneumonia in children, penicillin resistant pneumococci, and macrolide resistant pneumococci.
The mechanism of action of tibpenem is to inhibit the synthesis of bacterial cell walls, have high affinity for various bacterial penicillin binding proteins (PBPs), and play a bactericidal role.
Tibipenem has a higher affinity for PBP1A, 2X, or 2B of penicillin-resistant pneumococci than other oral antibiotics β- Lactam antibiotics.
Packaging & Transport
Payment
Company profile
Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem.FAQ:
Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.
Q2:What's your MOQ?
A: Our MOQ starts from 1kg.
Q3:Which kind of payment terms do you accept?
A: Payment by LC, T/T, D/P, PayPal, Western Union, Small-amount payment
Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
Q5. Are you manufacturer or trade company?
We are a comprehensive technology enterprise that focuses on the production and research and development of intermediates and fine chemicals.
Q6:How to contact us?
You can choose your interested products and send inquiry to us.You can dial our telephone directly, you will get our reply.
