Best Quality 2, 2-Dimethyl-1, 3-Dioxane-4, 6-Dione CAS 2033-24-1 Used in Chemicals

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Product origin: Xinxiang, Henan, China
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US$ 22 ~ 30

Description

Brief Introduction

 

Brief Introduction
NameMeldrum's Acid
Synonyms2,2-Dimethyl-1,3-Dioxane-4,6-Dione
Isopropylidene Malonate
Malonic Acid Cyclic Isopropylidene Ester
Cyclic Isopropylidene Malonate
CAS2033-24-1
EINECS217-992-8
Molecular FormulaC6H8O4
Molecular weight144.13
Pureness≥99%
Production Capacity200 tons/month

Properties

Properties
Density1.1311 (rough estimate)
Melting Point92-96°C(lit.)
Boling Point182.71°C (rough estimate)
Flash Point150.1°C
Water Solubility2.5 g/100 mL (20 ºC)
Vapor Presure0.044-133Pa at 25ºC
AppearanceWhite crystalline powder
Merck145817
BRN117310
pKa5.1(at 25ºC)
Storage Condition2-8°C
Refractive Index1.4434 (estimate)
MDLMFCD00006638
InChIInChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3
InChIKeyGXHFUVWIGNLZSC-UHFFFAOYSA-N

Product Description

Product Description
Due to its unique structure and the vast array of substituents that can be attached to its core, Meldrum's acid is a molecule with exceptional chemical properties. In water, it has a remarkably low pKa value of about 4.9. Its C5 position is readily involved in electrophilic substitution reactions whereas the C4 and C6 positions are easily attacked by nucleophiles. At elevated temperatures Meldrum's acid undergoes distinctive decomposition pathways, which can be used in cycloaddition and acylation reactions. 

Solubility
Meldrum's acid or 2,2-dimethyl-1,3-dioxane-4,6-dione is an organic compound with formula . Its molecule has a heterocyclic core with four carbon and two oxygen atoms; the formula can also be written as [−O− (C (CH3)2)−O− (C=O)− (CH2)− (C=O)−]  . It is a crystalline colorless solid, sparingly soluble in water. It decomposes on heating with release of carbon dioxide and acetone.

Stability

  1. It will not decompose if used and stored according to specifications. No known hazard reactions. Avoid oxides, moisture/moisture.
  2. It's very stable and can be stored for a long time at room temperature.
Storage Attentions
Keep the storage device sealed and stored in a cool, dry place. Ensure that the workshop is well ventilated or vented.

Application

Application

1. It's used as a pharmaceutical intermediate. The ring (sub) isopropyl malonate can be used as an intermediate in pharmaceutical synthesis, and it can be used to prepare the compound 3-oxo-4-phenylvalerate Ethyl, further preparation of 3, 4-disubstituted-6-phenylethylpyridinone HIV-1 reverse transcriptase inhibitors.
2. It's used in organic synthesis.The protective reagent is obtained by aldol condensation and reduction with triethylamine formaldehyde. the benzyl substituted michele acid is hydrolyzed, lost CO2 and chlorosulfonic acid for Friedel-Crafts cyclization to produce 2, 3-dihydro-2-indanone. Accelerate the Noven Gall concentration reaction between aldehyde and Michaelis acid in ionic liquid (Knoevenagel condensations).

 

 

Packaging & Transport

Packaging & Transport

 

Payment

Payment

 

Company Profile

Company profile

Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem. 

The company is located in the economic development zone in Xinxiang City, Henan Province, enjoying a superior location and convenient transportation.

The company is armed with top-notch technicians, advanced production equipments and testing instruments as well as perfect Q.C. system. Products are sold not only around China, but also to Europe and the US as well as the Asia-Pacific Region.

Upholding the Strategic Policy of "Survive through Quality, Develop through Technology", we sincerely welcome the cooperation of friends from all walks of life for a bright future.


FAQ

FAQ:
Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.

Q2:What's your MOQ?
A: Our MOQ starts from 1kg.

Q3:Which kind of payment terms do you accept?
A: Payment by LC, T/T, D/P, PayPal, Western Union, Small-amount payment

Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5. Are you manufacturer or trade company?
We are a comprehensive technology enterprise that focuses on the production and research and development of intermediates and fine chemicals.


Q6:How to contact us?
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