High Purity Beta-Methyl Vinyl Phosphate CAS 90776-59-3 Used in Organic Synthesis Raw Materials

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Product origin: Xinxiang, Henan, China
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US$ 420 ~ 588

Description

Brief Introduction

Brief Introduction
NameBeta-Methyl Vinyl Phosphate 
Synonymsbeta-Methyl vinyl phosphate MAP
(4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate
(1R,5S,6S)-2-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate
(1R,5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-[(diphenylphosphono)-oxy]-1-methylcarbapen-2-em-3-carboxylic acid 4-nitrobenzyl ester
[4R-[4α, 5β,6β(R*)]]-3-[(diphenoxyphosphinyl)oxy]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
CAS90776-59-3
EINECS618-646-2
Molecular FormulaC29H27N2O10P
Molecular Weight594.51
 

Properties

Properties
Density1.47±0.1 g/cm3(Predicted)
Melting Point126-130ºC
Boling Point722.4±60.0 °C(Predicted)
Flash Point390.671°C
SolubilityChloroform (Slightly), Methanol (Slightly)
Vapor Presure0mmHg at 25°C
AppearanceWhite Powder
ColorWhite to Off-White
pKa14.36±0.20(Predicted)
Storage ConditionSealed in dry,2-8°C
Refractive Index1.653
UsageUsed as a pharmaceutical intermediate, also can be used for the preparation of pivol ester of tibipenem.
Packing20kg/barrel(Lined with a plastic bag, sealed with an aluminum foil bag, and with a paper cylinder outside)
Specific spin[α]D20 =+45°~+55°
PSA167.23
LogP2.13
Density1.5±0.1 g/cm3
MDL NumberMFCD01318092
InChIInChI=1/C29H27N2O10P/c1-18-25-24(19(2)32)28(33)30(25)26(29(34)38-17-20-13-15-21(16-14-20)31(35)36)27(18)41-42(37,39-22-9-5-3-6-10-22)40-23-11-7-4-8-12-23/h3-16,18-19,24-25,32H,17H2,1-2H3/t18-,19-,24-,25-/m1/s1

Product Description

Product Description

Beta-Methyl Vinyl Phosphate is a pharmaceutical intermediate that can be used to prepare tibipenem pivoxil. Tibipenem pivoxil, chemically known as (+) - (4R, 5S, 6S) - 6 - [(1R) - hydroxyethyl] - 4-methyl-7-oxo-3 [[1 - (2-thiazolin-2-yl) - 3-azacyclobutanyl] sulfur] - 1-azabicyclic [3.2.0] hept-2-en-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy) methyl ester, is a carbapenem antibiotic. After absorption in the intestinal tract, Tibipenem pivoxil is metabolized to Tibipenem, showing antibacterial activity.
Tibipenem has broad-spectrum antibacterial activity against gram-positive bacteria and gram-negative bacteria, including Staphylococcus, Streptococcus, Pneumococcus (including PRSP), and Moraxella catarrhalis (including β- Lactam producing bacteria), Haemophilus influenzae (including ampicillin resistant Haemophilus influenzae) have strong antibacterial activity. In particular, compared to previous oral antibiotics, tibpenem exhibits extremely strong antibacterial activity against pathogenic bacteria such as otitis media, paranasal sinusitis, and pneumonia in children, penicillin resistant pneumococci, and macrolide resistant pneumococci.
The mechanism of action of tibpenem is to inhibit the synthesis of bacterial cell walls, have high affinity for various bacterial penicillin binding proteins (PBPs), and play a bactericidal role.
 Tibipenem has a higher affinity for PBP1A, 2X, or 2B of penicillin-resistant pneumococci than other oral antibiotics β- Lactam antibiotics.
 


 

 

Packaging & Transport

Packaging & Transport

 

Payment

Payment

 

Company Profile

Company profile

Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem. 

The company is located in the economic development zone in Xinxiang City, Henan Province, enjoying a superior location and convenient transportation.

The company is armed with top-notch technicians, advanced production equipments and testing instruments as well as perfect Q.C. system. Products are sold not only around China, but also to Europe and the US as well as the Asia-Pacific Region.

Upholding the Strategic Policy of "Survive through Quality, Develop through Technology", we sincerely welcome the cooperation of friends from all walks of life for a bright future.


FAQ

FAQ:
Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.

Q2:What's your MOQ?
A: Our MOQ starts from 1kg.

Q3:Which kind of payment terms do you accept?
A: Payment by LC, T/T, D/P, PayPal, Western Union, Small-amount payment

Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5. Are you manufacturer or trade company?
We are a comprehensive technology enterprise that focuses on the production and research and development of intermediates and fine chemicals.


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