Wholesale/Supplier Pharmaceutical Intermediate Mildronate CAS 76144-81-5

1. Mildronate powder is a novel cardioprotective agent.

2.Mildronate acts on mitochondria at the cellular level to improve myocardial energy
metabolism. In view of these drugs and other anti-myocardial ischemia significantly different,
also known as cell anti-ischemic drugs.

3. Mildronate is a structural analog of carnitine that competes in the inhibition of butyrate
betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits
the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine
biosynthesis can reduce the concentration of intracellular free carnitine and prevent
isoproterenol-induced acyl carnitine accumulation.

Therefore, the drug has a significant protective effect on the myocardium, resulting in this
protective effect at the same time on the hemodynamic parameters had no significant
effect, cardiac blood supply and cardiac oxygen consumption was no significant change