Description
Factory Supply Valsartan Sacubitril Powder CAS 936623-90-4 Valsartan Sacubitril For Pharmaceutical Intermediate
| Product Name | Factory Supply Valsartan Sacubitril Powder CAS 936623-90-4 Valsartan Sacubitril For Pharmaceutical Intermediate |
| Appearance | powder |
| cas | 936623-90-4 |
| Assay | 99% |
| Keywords | Valsartan Sacubitril;Valsartan Sacubitril Powder;Valsartan Sacubitril CAS 936623-90-4 |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
| What is Valsartan Sacubitril?LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure. |
Function of Valsartan Sacubitril LCZ696, a first-in-class inhibitor of dualacting angiotensin-2 type-I receptor and neprilysin inhibitors, was developed as a molecule composed of molecular moieties of valsartan and neprilysin inhibitor prodrug AHU377 in a 1:1 ratio. Several phase 2 randomised clinical trials have been done or are underway in patients with hypertension. In a proof-of-concept randomised trial, LCZ696 was compared with valsartan in 1328 patients with mild-to-moderate hypertension, and provided fully additive reduction of blood pressure. No cases of angio-oedema were reported in the 8 week treatment period. This tolerance should be confirmed, particularly in black patients, for whom omapatrilat resulted in a higher occurrence of angio-oedema than in white patients. Indeed, in the proof-of-concept trial only about 8% of patients were black.
Pharmaceutical API Anti Heart Failure Raw Powder CAS 936623-90-4 LCZ696
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Powder Raw Material Manufacturer, Powder Raw Material FactoryQ: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount ?
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders ?
A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q: How to start orders or make payments ?
A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint ?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Pharmaceutical API Anti Heart Failure Raw Powder CAS 936623-90-4 LCZ696
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