Complaint
Product Name: Rutin
Botanic Name: Sophora japonica
Specification: 95% NF11
Test Method: UV
Part of used: Flower
Appearance: Yellow green fine powder
| PRODUCT SPECIFICATIONS | ||
| Product Name: | Rutin 95% | |
| Botanic Name: | Sophora japonica L. | |
| Scientific name(Family/Genus/Species) | Fabaceae/Styphnolobium/S.japonicum | |
| Part of plant | Flower | |
| Solvent extraction | 50% water & 50% ethanol | |
| Country of Origin: | China | |
| Excipent | None | |
| ANALYSIS ITEMS | SPECIFICATION | TEST METHOD |
| Appearance | Fine powder | Organoleptic |
| Color | Yellow green | Visual |
| Odour & Taste | Characteristic | Organoleptic |
| Identification | Identical to R.S. sample | HPTLC |
| Rutin | NLT 95.0% | UV |
| Extract ratio | 5:1 | |
| Solubility | Not soluble in water | Organoleptic |
| Hydrocarbons PAHs | ≤ 50 ppb -Reg.UE 1933/2015 | GC-MS |
| Benzo(a)pyren | ≤ 10 ppb -Reg.UE 1933/2015 | GC-MS |
| Radioactivity | ≤ 600 Bq/Kg -Reg. CE 1409/2009 | Gamma spectrometry |
| Apparent density | ≥ 0.15g/ml | Eur.Ph. <2.9.34> |
| Sieve Analysis | 100% through 80 mesh | USP39 <786> |
| Loss on drying | 5.5%-9.0% | Eur.Ph.9.0 [2.5.12] |
| Total Ash | ≤ 5.0% | Eur.Ph.9.0 [2.4.16] |
| Lead (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Mercury(Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Heavy metal | ≤ 10.0 mg/kg | Eur.Ph.9.0 <2.4.8> |
| Solvents Residue | Conform Eur.ph. 9.0 <5,4 > and EC European Directive 2009/32 | Eur.Ph.9.0<2.4.24> |
| Pesticides Residues | Conform Regulations(EC) No.396/2005 including annexes and successive updates Reg.2008/839/CE | Gas Chromatography |
| Aerobic bacteria(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Yeast/Moulds(TAMC) | ≤100 cfu/g | USP39 <61> |
| Bile-tol.gram- b./Enterobact.: | ≤100 cfu/g | |
| Escherichia coli: | Absent in 1g | USP39 <62> |
| Salmonella spp: | Absent in 25g | USP39 <62> |
| Staphylococcus aureus: | Absent in 1g | |
| Listeria Monocytogenens | Absent in 25g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Rutin, also called rutoside, quercetin-3-0-rutionside and sophorin, is the glycoside combining the flavonol quercetin and the disacchride rutinose(alpha-L-rhamnopyranosyl-(1-6)-beta-alpha-glucopyranose). It is a citrus flavonoid found in a wide variety of plants including citrus fruit.
Rutin is one of the phenolic compounds found in the invasive plant species Carpobrotus edulis and contributes to the antibacterial properties of the plant.
1) Rutin can be cooling bleeding, purge liver-fire, with anti-inflammatory effects
2) Rutin with vitamin P-like effect, anti-viral
3) Rutin also has a role in inhibiting aldose reductase
4) Rutin is a phenolic antioxidant and has been demonstrated to scavenge superoxide radicals
5) Rutin can chelate metal ions, such as ferrous cations. Ferrous cations are involved in the so-called Fenton reaction, which generates reactive oxygen species
6) Rutin may also modulate the respiratory burst of neutrophils
Application:
1. Rutin could applied in pharmaceutical field, it can be made into suppository, lotion, injection, tablets, capsules, etc.
2. Rutin could applied in health product field, it is mainly used in female health product and health medicine for delaying aging and preventing hematological disease and cancer.
3. Rutin could applied in food field, it is mainly used in kinds of beverage, liquor and foods to enhance human immunity and anti-aging.
