English name: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid English alias: Silver Pefloxacin; Pefloxacinum; PFLX; Abactal; Pefloxacine CAS Number: 70458-92-3 Molecular formula: C17H20FN3O3 Molecular weight: 333.35700 Accurate quality: 333.14900 PSA: 65.78000 LogP: 1.61340 Physical and chemical properties Density: 1.32 g/cm3 Boiling point: 529.1ºC at 760 mmHg Flash point: 273.8ºC Refractive index: 1.593 Vapor pressure: 5.05E-12mmHg at 25°C [1] Security Information Dangerous goods transport code: UN 3082 Hazard category code: R51/53 Safety instructions: S61 RTECS number: WM6250000 Dangerous goods mark: N Molecular structure data 1. Molar refractive index: 85.63 2. Molar volume (cm/mol): 252.4 3. Isotonic specific volume (90.2K): 679.3 4. Surface tension (dyne/cm): 52.4 5. Polarizability (10-24cm3): 33.94 Computational chemistry data 1. Hydrophobic parameter calculation reference value (XlogP): none 2. Number of hydrogen bond donors: 1 3. Number of hydrogen bond acceptors: 7 4. Number of rotatable chemical bonds: 3 5. Number of tautomers: none 6. Polar surface area of topological molecules 64.1 7. Number of heavy atoms: 24 8. Surface charge: 0 9. Complexity: 545 10. Number of isotope atoms: 0 11. Determine the number of atomic stereo centers: 0 12. Uncertain the number of atomic stereocenters: 0 13. Determine the number of chemical bond stereo centers: 0 14. Uncertain the number of chemical bond stereo centers: 0 15. Number of covalent bond units: 1
See Norfloxacin for clinical indications. Intravenous administration can still be used for severe cases of pulmonary infection, and it can also be used for gram-negative bacilli sepsis. The treatment of sepsis often needs to be combined with antibacterial drugs that have a synergistic effect. Used for serious infections of G-bacteria and Staphylococcus in adults such as sepsis, endocarditis, bacterial meningitis, infections of the respiratory tract, urethra, kidney, ENT, gynecological diseases, abdomen, liver and gallbladder, osteoarthritis and skin infections, etc.