Cyproterone Acetate Powder CAS 427-51-0 API Cyproterone Acetate, Active Pharmaceutical Ingredient

Cyproterone acetate powder CAS 427-51-0 API cyproterone acetate,active pharmaceutical ingredient

Cyproterone acetate (CPA), is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills. It is formulated and used both alone and in combination with an estrogen and is available for use both by mouth and by injection into muscle.

Androgen dependent conditions

Cyproterone Acetate is used in the treatment of prostate cancer, precocious puberty, androgen-dependent skin and hair conditions such as acne, seborrhea, hirsutism (excessive hair growth), and androgenic alopecia (pattern hair loss), hyperandrogenism (e.g., in PCOS), and to reduce sex drive in sex offenders or men with paraphilias or hypersexuality. Cyproterone Acetate is also widely used as a component of feminizing hormone therapy for transgender women. In the U.S., where Cyproterone Acetate is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer.

In the treatment of acne in women, a formulation of low-dose Cyproterone Acetate in combination with EE has been found to result in overall improvement in 75 to 90% of patients, with responses approaching 100% improvement.

Birth control

The combination of Cyproterone Acetate and EE, a formulation sometimes referred to as co-cyprindiol, has been available as a combined oral contraceptive since 1978.This formulation is taken once daily for 21 days, followed by a 7-day free interval.Cyproterone Acetate has also been available in combination with estradiol valerate (brand name Femilar) as a contraceptive in Finland since 1993.

Cyproterone Acetate is available in the form of oral tablets alone (high-dose; 10 mg, 50 mg, 100 mg) or in combination with ethinylestradiolor estradiol valerate (low-dose; 2 mg Cyproterone Acetate) and in the form of ampoules for intramuscular injection (high-dose; 100 mg/mL, 300 mg/3 mL; brand name Androcur Depot).The high-dose formulations are used to treat prostate cancer and certain other androgen-related indications while the low-dose formulations which also have an estrogen are used as combined birth control pills and are used in menopausal hormone therapy for the treatment of menopausal symptoms.