Complaint
| Catalog No. | BS3474 |
|---|---|
| Product Name | CD63 (K156) polyclonal antibody |
| Applications | WB IHC |
| Alternative Name | CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63; MLA1; TSPAN30 |
| Swiss-Prot | P08962 |
| Host | Rabbit |
| Reactivity | Human |
| Application_all | WB: 1:500~1:1000 IHC: 1:50~1:200 |
| Product | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Purification&Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Storage&Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Specificity | CD63 (K156) polyclonal antibody detects endogenous levels of CD63 protein. |
| BiowMW | ~ 30 kDa |
| Note | For research use only, not for use in diagnostic procedure. |
| Immunogen | Synthetic peptide, corresponding to amino acids 111-160 of Human CD63. |
Background
CD63 (also known as LAMP-3, Melanoma-associated antigen ME491, TSPAN30, MLA1 and OMA81H) is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome.
