Manufacturer Supply CAS 162359-56-0 Fingolimod

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Product origin: Guangzhou, Guangdong, China

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Description

Product name	Fingolimod hydrochloride
CAS	162359-56-0
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Fingolimod hydrochloride
CAS:162359-56-0
MF:C19H34ClNO2
MW:343.93
EINECS:680-631-1
Mol File:162359-56-0.mol
Melting point:102-107°C
storage temp. -20°C Freezer
solubility water: soluble10mg/mL, clear
form powder
color white to beige
Merck 14,4083

Description
Fingolimod hydrochloride is the first oral drug for the treatment of multiple sclerosis. It is successfully developed by the pharmaceutical company Novartis, and it has been approved for marketing by the US Food and Drug Administration (FDA). The recommended dose is 0.5mg once a day for oral administration.
Multiple sclerosis is a debilitating neurological disease that can cause the patient to lose a sense of balance, appear muscle spasms and other movement disorders. The disease has been treated with injectable drugs. This kind of medication brought great inconvenience to patients.
Fingolimod is a sphingosine-l-phosphate (S1PR) receptor modulator. After phosphorylation, It is bound to s1P receptor that is on the surface of lymphocyte, which will change lymphocyte migration, and promote cells into the lymphatic tissue, and prevent lymphocytes from leaving the lymphoid tissue and get into the graft. Thereby, it will prevent these cells from infiltrating the central nervous system (CNS), which achieves the effect of immunosuppression. According to the drug's introduction, drugmaker Novartis said that this process of pharmacological effects is reversible. If medication is stopped, the level of lymphocytes in circulating system will return to normal.
The above information is edited by the chemicalbook of Kui Ming.

PHARMACOLOGIC INHIBITION OF ALDOSTERONE
Cyclosporin, heparin sodium, and calcium channel blockers specifically inhibit aldosterone production from the zona glomerulosa. Cyclosporin blocks angiotensin II-induced aldosterone production and inhibits "growth" and steroidogenic capacity of adrenocortical cells.63 The latter effect may be caused by an impairment of protein synthesis. Additionally, cyclosporin and tacrolimus (FK506) inhibit MR transcription activity without affecting aldosterone binding.64 Polysulfated glycosaminoglycans, such as heparin sodium, impair aldosterone biosynthesis. With prolonged administration, heparin sodium can produce significant hypoaldosteronism with severe hyperkalemia65 .

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

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