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roduct name :Tetracaine HCL
Other name : Tetracaine Hydrochloride
CAS register number: 136-47-0
EINECS : 205-248-5
Molecular formula : C15H25ClN2O2
Molecular weight : 300.82
Assay : 98.5%
Appearance : White crystalline powder
Package :1kg/aluminium foil bag or as required
Usage : Can be used as pharmaceutical Local anesthetics
Tetracaine Description:
Tetracaine HCL is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium etoxide.
Tetracaine, also known as Amethocalne, Dlcalne, Pontocaine, Decicaine, is a kind of Local Anesthetic. It is highly soluable in Non-polar solvent, and combines with Plasma protein by 85%.
Tetracaine takes effect very fast. It just needs 1-2 min. Usually, its half life is 5-10 min. And it can lasts for 20 ~ 40min.
It is widely used as pain-killer in Mucosal surface anesthesia, Conduction anesthesia, Epidural anesthesia, Spinal anesthesia, Ophthalmic topical anesthesia and so on.
Tetracaine is more efficient than Procaine. It is 10-15 times more effective than it.
Tetracaine Application:
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
What is the difference between the anesthetic intensity of tetracaine hydrochloride powder and lidocaine, procaine and Dimethocoine?
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Tetracaine
Tetracaine HCl
Tetracaine Hydrochloride
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Benzocaine
Benzocaine HCl
Lidocaine
Lidocaine HCl
Lidocaine Hydrochloride
Procaine
Procaine Hydrochloride
| Item of Analysis | Standard | Result of Analysis |
| Description | White or light yellow, waxy solid | White solid |
| Identification | A. Dissolve 100 mg in 10 mL of dilut hydrchloric acid(1 in 120),and add 1 mL of potassium thiocyanate solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: it melts between 130 and 132 . | Conforms |
| B: By UV, To match with working standard | Complies | |
| Chromatographic purity | Conform to standard | Complies |
| Loss on drying | ≤0.50% | 0.1% |
| Resiue on ignition | ≤0.10% | 0.05% |
| Melting range | 41ºC~46ºC | 42.5ºC~43.0ºC |
| Residual solvent | Ethanol≤0.5% | Not detected |
| Acetoe≤0.5% | 0.007% | |
| 4-Methyl-2-pentanone≤0.5% | Not detected | |
| DCM≤0.06% | Not detected | |
| PETOLEUM ETHER≤0.5% | 0.12% | |
| Isoprepyl ether≤0.5% | 0.03% | |
| Assay | 99.0%~101.0% | 99.6% |
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