Pharmaceuticals Chemical Anti-Cancer Methotrexate Powder CAS 59-05-2

Min.Order: 1

Product origin: Jinan, Shandong, China

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US$ 50 ~ 100

Description

Name	Methotrexate
Synonyms	(+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular Formula	C20H22N8O5
Molecular Weight	454.44
CAS Registry Number	59-05-2
EINECS	200-413-8

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

Test Item	Analysis Specification	Result
Description	Orange yellow crystalline powder; Novisible evidence of contamination by foreign matter	Yellow
Identification A:	IR spectrum exhibits maxima only at the same wavelengths as that of a similar preparation of the USP reference standard	Conforms
Identification B:	UV spectrum exhibits maxima and minima only at the same wavelengths as that of a similar preparation of the USP reference standard	Conforms
Residue on ignition	Not more than 0.1%	0.08%
Specific Rotation	+19° to +24°	+20.6°
Water content	Not more than 12.0%	10.30%
Assay(calculated on anhydrous basis)	98.0% to 102.0%	99.40%
Chromatographic Purity	Total Not more than 2.0%	0.70%
	Individual Not more than 0.5%	0.20%

Used as a antineoplastic and antirheumatic.

Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.

Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.

1.Can I get some samples?
Yes, usually a 10-20g sample.

2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.

3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.

4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

5. What is the shelf life for the products?
Most products shelf life 24-36 months.

6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.

7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.