Product Name:Neomycin sulfate CAS:1405-10-3 MF:C23H48N6O17S MW:712.72 EINECS:215-773-1 Mol File:1405-10-3.mol Melting point:>187°C (dec.) alpha D20 +54° (c = 2 in H2O) refractive index 56 ° (C=10, H2O) Flash point:56ºC storage temp. 2-8°C solubility H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. form powder color white to slightly yellow PH5.0-7.5 (50g/l, H2O, 20ºC) Water Solubility Soluble in water
Chemical PropertiesNEOMYCIN SULFATE is white or yellowish-white powder, hygroscopic. UsesNEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. UsesNEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures. UsesNeomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use.
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