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Detail:
Chemical name: Pramiracetam
MF: C14H27N3O2
MW: 269.38
CAS: 68497-62-1
Appearance: white powder
Purity: over 99%
Usage: cognitive enhancers
Description:
Pramiracetam is a drug belonging to the racetam family of cognitive enhancers. Pramiracetam may improve memory and enhance learning ability. It also has the potential to treat amnesia and help with brain injuries. Read on to see the potential uses, mechanisms, and side effects of pramiracetam.
What is Pramiracetam?
Pramiracetam (also known as Pramistar) is a cognitive enhancer (nootropic) that is synthesized from piracetam, the original racetam, by substituting the amide group in piracetam with a Ditropan-2-arylamino ethyl group. This substitution allows pramiracetam to be more potent than piracetam.
Pramiracetam was developed in 1979 by Parke-Davis, a division of the Warner-Lambert pharmaceutical company. Pramiracetam was at first distributed under the brand name Primastar. Now, it is part of Pfizer, since Warner-Lambert merged with Pfizer in 2000.
Pramiracetam is found to increase rats' object recognition with a significantly lower dose when compared to piracetam. Piracetam required 13 times the dose of pramiracetam to have the same effect.
Pramiracetam Mechanism of Action:
Acetylcholine (ACh) is a neurotransmitter involved in learning and memory. Pramiracetam increased the rate of choline uptake into the rat brain cells by 30 to 37%. Increased uptake of choline provides more choline as a source to build ACh. This effect lasts approximately 24 hours.
Even when rats were given scopolamine, a substance that reduces choline concentration in the brain, treatment with pramiracetam prevented choline depletion.
a compound that is known to play a role in memory and learning. Pramiracetam increases production in the brain.
The action of pramiracetam and other racetams depends on adrenal hormone availability. In rats, racetams, including pramiracetam, lost their "memory-improving effect" after the animals had their adrenal glands removed. Inhibition of adrenal hormone production also suppressed the memory-improving effects of pramiracetam in mice.
However, higher levels of adrenal hormones aldosterone or corticosterone (cortisol equivalent) also blocked the memory-improving effects of this drug in mice in a dose-related manner.
Specification:
| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot, RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
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68497-62-1 Nootropic Raw Powder Pramiracetam for Brain Improvement
