Product Name:Candesartan CAS:139481-59-7 MF:C24H20N6O3 MW:440.45 EINECS:604-138-8 Mol File:139481-59-7.mol Melting point:183-185°C Boiling point:754.8±70.0 °C(Predicted) Density 1.41±0.1 g/cm3(Predicted) RTECS DD6671000 storage temp. -20°C Freezer pka2.06±0.10(Predicted) Water Solubility Soluble in ethyl acetatee, methanoll, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Description Candesartan, like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.
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