Complaint
Diosmin, also known as Amelan, is a drug for the treatment of various symptoms associated with acute hemorrhoids and also for the treatment of various symptoms associated with venous lymphatic insufficiency (heavy legs, pain, morning soreness). Discomfort).
The role of diosmin is as follows:
1. Has a specific affinity for the venous system, enhances the tension of the veins without affecting the arterial system;
2. For the microcirculation system, it can reduce the viscosity of blood, increase the flow rate and reduce stasis;
3. For the lymphatic system, it can enhance lymphatic vessel contraction and lymphatic drainage speed, accelerate the return flow and reduce edema.
4. The commercially available diosmin adopts the micronization technology, the contact area after using the drug increases, the absorption is more, and the bioavailability is higher. It is suitable for various hemorrhoids and acute attacks of hemorrhoids, and can also treat chronic venous insufficiency, such as varicose veins, lower extremity ulcers, etc.
| Product name | Diosmin |
| CAS | 520-27-4 |
| Appearance | white powder |
| Assay | 99% |
| Storage | Cool and Protect from light |
1.Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
2.Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
3.Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
4.Diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
5.At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.
6.Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.Diosmin leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.
Application:
Diosmin is mainly used in pharmaceutical feild for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.
Usages:
uIt has the same function as Vitamin.
uIt can reduce the brittleness and abnormal vascular permeability,
utreatment for control of hypertension and arteriosclerosis, used in the treatment of capillary fragility effect stronger than rutin, hesperidin, and has the characteristics of low toxicity.
uTreatment of hemorrhoid, Chronic Venous strict inequality
| Items | Specifications | Result |
| Appearance | Greyish-yellow or light yellow hygroscopic powder | Complies |
| Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solution of alkali hydroxides. | Complies |
| Identification | A: IR B: HPLC | Complies |
| TEST | ||
| Related substances Impurity A(Acetoisovanillone) Impurity C(Isorhoifolin) Impurity E(Linarin) Impurity F(Diosmitin) | ≤1% ≤3% ≤3% ≤3% | Absence 2.96% 1.06% 0.83% |
| Others impurities | ≤1% | Absence |
| Total other impurities | ≤3% | 1.06% |
| Heavy metals Iodine Residual Merpholine | ≤10ppm ≤200ppm ≤1.0ppm | Comply <200ppm <1.0ppm |
| Water Sulfated Ash | ≤6.0% ≤0.5% | 4.11% 0.36% |
| Assay HPLC Diosmin Hesperidin | 81.0%~85.0% 7.0~9.0% | 81.78% 8.25% |
| Residual solvents Methano l Pyridin e | ≤3000ppm ≤200ppm | Absence 185ppm |
| Particle size | 95% pass5um | Complies |
| Microbiological test Total plate count Yeasts and molds Escherichia. Coli Salmonellae Staph.aureus | ≤1000CFU/g ≤100CFU/g Absence in 1g Absence in 10g Absence in 1g | 120CFU/g 30CFU/g Absence Absence Absence |
| Conclusion | The test results conform to Specification. | |
