Product Name:HEPARIN CALCIUM CAS:37270-89-6 MF: MW:0 EINECS: Mol File:Mol File solubility Freely soluble in water form neat
Description Chemical PropertiesWhite or almost white, hygroscopic powder. UsesAnticoagulant. Mineralocorticoid Deficiency Paul M. Stewart, Marcus Quinkler, in Endocrinology, 2010
PHARMACOLOGIC INHIBITION OF ALDOSTERONE Cyclosporin, heparin sodium, and calcium channel blockers specifically inhibit aldosterone production from the zona glomerulosa. Cyclosporin blocks angiotensin II-induced aldosterone production and inhibits "growth" and steroidogenic capacity of adrenocortical cells.63 The latter effect may be caused by an impairment of protein synthesis. Additionally, cyclosporin and tacrolimus (FK506) inhibit MR transcription activity without affecting aldosterone binding.64 Polysulfated glycosaminoglycans, such as heparin sodium, impair aldosterone biosynthesis. With prolonged administration, heparin sodium can produce significant hypoaldosteronism with severe hyperkalemia65 .
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