Complaint
Overview: Tamiflu is one of the top ten veterinary antibiotics, its antibacterial spectrum is similar to macrolide antibiotics, mainly against Gram-positive bacteria, with strong inhibitory effects on Staphylococcus aureus, Streptococcus, Mycoplasma, Actinomyces pleuropneumoniae and porcine dysentery with dense spirochetes; its effects on mycoplasma are stronger than those of macrolides.
Antibacterial spectrum: strong inhibitory effect on Mycoplasma, Actinomyces pleuropneumoniae, Actinomyces dysenteriae and intracellular Lawsoniae, etc.; better effect on Mycoplasma than macrolides.
| Common Name | Tiamulin | ||
|---|---|---|---|
| CAS Number | 55297-95-5 | Molecular Weight | 493.742 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 563.0±50.0 °C at 760 mmHg |
| Molecular Formula | C28H47NO4S | Melting Point | 147-148ºC |
| MSDS | ChineseUSA | Flash Point | 294.3±30.1 °C |
| Items | Standard | Results |
| APPEARANCE | Off white to white powder | White powder |
| IDENTIFICATION | A: IR B: Retention time | Complies Complies |
| WATER | ≤0.5% | 0.06% |
| HEAVY METALS | ≤0.002% | Complies |
| ISOMERS | SFBD1≤0.15% | Undetected |
| SFBD2≤0.15% | Undetected | |
| SFBE≤0.15% | Undetected | |
| RELATED SUBSTANCES | SFBA-1≤0.15% | 0.04% |
| SFBMA≤0.15% | Undetected | |
| CHLORO-SFB≤0.15% | 0.05% | |
| DiSFBMA-SFB≤0.15% | 0.02% | |
| Methyl-SFB≤0.15% | Undetected | |
| Pentafluoro-phenol≤0.15% | Undetected | |
| Amino-SFB≤0.15% | Undetected | |
| Any unknown impurity≤0.1% | 0.04% | |
| Total impurity≤1.0% | 0.21% | |
| ASSAY | ≥99.0% | 99.8% |
Tiamulin is a semi-synthetic derivative of pleuromutilin. It is highly active against gram-positive organisms such as streptococci, staphylococci and highly active against mycoplasmas and serpulina (Treponema) hyodysenteriae. The range of values of Minimal Inhibitory Concentrations (MICs) against streptococci and staphylococci is between 0.015 and 0.15ug/ml, with a few exceptions among streptococcus faecalis strains.
The most efficient biological activity of Tiamulin is evident in the area of mycoplasmas control, surpassing such antibiotics as Tetracycline HCl and Tylosin tartrate, the two antibiotics widely used for the treatment of infections. The MIC values of Tiamulin against strains of mycoplasmas range from 0.004 to 6.25ug/ml. Tiamulin acts bacteriostatically.
