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1.Lidocaine hcl is a local anesthetic and antiarrhythmic drug. It is clinically used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including in the thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block.
2.Lidocaine hcl is an amide local anesthetic. With the dose increased, the role or toxicity increased, there is an anti-convulsive effect with sub-poisoning plasma concentration; Blood concentration of more than 5μg • ml-1 can occur convulsions.Item of Analysis | Standard | Result of Analysis |
Description |
White or light yellow, waxy solid | White solid |
Identification | A. Dissolve 100 mg in 10 mL of dilut (1 in 120),and add 1 mL of potassium thiocyanate solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: it melts between 130 and 132 . | Conforms |
| B: By UV, To match with working standard | Complies | |
Chromatographic purity | Conform to standard | Complies |
Loss on drying | ≤0.50% | 0.1% |
Resiue on ignition | ≤0.10% | 0.05% |
Melting range | 41ºC~46ºC | 42.5ºC~43.0ºC |
Residual solvent | Ethanol≤0.5% | Not detected |
≤0.5% | 0.007% | |
4-Methyl-2-pentanone≤0.5% | Not detected | |
DCM≤0.06% | Not detected | |
≤0.5% | 0.12% | |
≤0.5% | 0.03% | |
Assay | 99.0%~101.0% | 99.6% |
Lidocaine Base Powder:
Lidocaine hcl is dissolved in water and is generally used as a liquid. Lidocaine base is not dissolved in water and is generally used as a cream.
Benzocaine Powder:
Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, teething pain, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body. Benzocaine is also used to numb the skin or surfaces inside the mouth, nose, throat, vagina, or rectum to lessen the pain of inserting a medical instrument such as a tube or speculum.
Tetracaine Base Powder:
Widely used in: hospitals, dentists, tattoos, fitness and other fields.
Mainly used for surface anesthesia of the eyes, nose, throat and urinary tract. It can cause convulsions after absorption, and then it is converted to respiratory depression, and is generally not used for anesthesia such as infiltration and conduction.
Procaine Base Powder:
Procaine Base is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid , which is then excreted by the kidneys into the urine.
If there is any problem, free replacement.
