Complaint
| Product Name | AMG 510 |
| Synonyms | CPD2809;AMG 510;Sotorasib;AMG-510,AMG510;AMG 510 USP/EP/BP;AMG-510 ATROPISOMER;AMG-510 atropisomer;Sotorasib (AMG-510);AMG-510;AMG 510;AMG510;chiral AMG 510, single isomer |
| CAS NO | 2252403-56-6 |
| Molecular Formula | C30H30F2N6O3 |
| Molecular Weight | 560.59 |
| Formulation | A solution |
| Boiling Point | 730.5±70.0 °C(Predicted) |
| Flash Point | 240 °C |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Grade | FG,IG |
| HS code | 2921 30 99 |
| Appearance | Solid powder |
| Storage | minus 20°C |
| Packing and Shipping | minus 20°C, stored under nitrogen |
| Usage | AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. |
| Product Description | AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors. |
AMG 510 (2252403-56-6) Description:
Sotorasib, also known as also known as AMG-510, is a potent KRAS G12C covalent inhibitor and the active atropisomer separated by chiral HPLC. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor
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