Action category treatment of sensitive bacterial infections.
Indications Amoxicillin is indicated for the following infections caused by sensitive bacteria (non-beta-lactamase producing strains) :
1. Otitis media, sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections caused by streptococcus hemolysis, streptococcus pneumoniae, staphylococcus or Haemophilus influenzae.
2. Urinary and reproductive tract infections caused by escherichia coli, Proteus mutans or Enterococcus faecalis.
3. Skin and soft tissue infection caused by streptococcus hemolytic, staphylococcus or escherichia coli.
4. Lower respiratory tract infections such as acute bronchitis and pneumonia caused by streptococcus hemolytic, streptococcus pneumoniae, staphylococcus or Haemophilus influenzae.
Acute simple gonorrhea.
6. This product can also be used for the treatment of typhoid fever, typhoid carriers and leptospirosis; Amoxicillin can also be used in combination with clarithromycin and lansoprazole to eradicate helicobacter pylori in stomach and duodenum and reduce the recurrence rate of gastrointestinal ulcer.
Adverse reactions 1. Gastrointestinal reactions such as nausea, vomiting, diarrhea and pseudomembranous enteritis.
2. Allergic reactions such as rashes, drug fever and asthma.
3. Anemia, thrombocytopenia, eosinophilia, etc.
4. Serum aminotransferase may be slightly increased.
5. Double infections caused by candida or drug-resistant bacteria.
6. Occasional central nervous system symptoms such as excitement, anxiety, insomnia, dizziness and abnormal behavior.
Contraindicated for patients with penicillin allergy and positive penicillin skin test.
Suitable for people infected by sensitive bacteria patients.
It is not suitable for people with penicillin allergy and positive penicillin skin test. Pregnant women should use this medicine only when absolutely necessary.
Precautions 1. Oral penicillins may occasionally cause anaphylactic shock, especially in patients with a history of allergy to penicillin or cephalosporins. A detailed history of allergy and skin test for penicillin must be conducted before use. In case of anaphylactic shock, emergency treatment should be carried out, including airway unblocked, oxygen uptake and treatment measures such as epinephrine and glucocorticoid.
2. Patients with infectious mononucleosis are prone to rash after using this product, and should be avoided.
3. Patients with a long course of treatment should be examined for liver and kidney function and blood routine examination.
4. Amoxicillin can cause false positives in urine sugar tests with Benedit or Fehling reagents.
5. Use with caution in the following cases:
(1) Patients with allergic diseases such as asthma and hay fever.
(2) Dosage may need to be adjusted for the elderly and severe renal impairment.
Animal reproductive tests of pregnant and lactating women showed that 10 times the human dose of amoxicillin did not damage the fertility of rats and mice and the fetus. However, there are insufficient controlled studies in humans, and since animal reproductive tests cannot fully predict human reactions, pregnant women should only use this product when it is really necessary. As a small amount of amoxicillin can be secreted in milk, nursing mothers may lead to infant allergies.
Children's daily dose according to body weight 20-40mg /Kg, once every 8 hours; For infants under 3 months of age, daily dose should be 30mg/Kg of body weight once every 12 hours.
The elderly should take 0.5g medicine once for adults, once every 6-8 hours, and the daily dose should not exceed 4g.
Drug interactions 1. Benemedicine competitively reduces renal tubule secretion of the drug, and the combination of the two causes increased blood concentrations and extended half-life of amoxicillin.
2. Chloramphenicol, macrolides, sulfonamides and tetracycline interfere with the antibacterial effect of amoxicillin in vitro, but its clinical significance is unknown.
Overdoses in a prospective study of 51 pediatric patients suggest that amoxicillin does not cause significant clinical symptoms when administered at doses up to 250mg/Kg. It has been reported that renal insufficiency and oliguria were caused by amoxicillin overdose in a small number of patients, but the renal damage was reversible after withdrawal of amoxicillin.
Drug toxicity amoxicillin is penicillin antibiotics, streptococcus pneumoniae, hemolytic streptococcus and other streptococcus, non-penicillinase-producing staphylococcus, enterococcus faecalis and other aerobic gram-positive coccus, The β -lactamase-producing strains of aerobic gram-negative bacteria such as Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and Helicobacter pylori showed good antibacterial activity. Amoxicillin plays a bactericidal role by inhibiting the synthesis of bacterial cell wall, which can make the bacteria quickly become spheroid and dissolve and break.
The drug is absorbed rapidly after oral administration, about 75% ~ 90% can be absorbed from the gastrointestinal tract, and the effect of food on drug absorption is not significant. The peak plasma concentrations (Cmax) of 0.25g and 0.5g were 3.5-5.0 mg/L and 5.5-7.5 mg/L, respectively, and the peak time was 1-2 hours. This product is well distributed in most tissues and body fluids. The mean sputum concentrations of patients with acute pneumonia or chronic bronchitis were 0.52mg/L and 0.53mg/L for 2-3 hours and 6 hours after oral administration of 0.5g, respectively, while the plasma concentrations were 11mg/L and 3.5mg/L during the same period. In children with chronic otitis media, the concentration of the drug in the middle ear fluid was 6.2mg/L 1 ~ 2 hours after oral administration of 1g of the drug. The concentration in cerebrospinal fluid of 2 hours after tuberculous sex meningitis patient takes orally this product 1g is 0.1 ~ 1.5mg/L, equivalent to 0.9% ~ 21.1% of blood drug concentration in the same period. This product can pass through the placenta, in the umbilical cord blood concentration is 1/4 to 1/3 of the maternal blood concentration, in milk, sweat and tears also contain trace. The protein binding rate of amoxicillin was 17% ~ 20%. The blood elimination half-life (T1/2) of this product is 1 ~ 1.3 hours. After taking the drug, about 24% ~ 33% of the dose is metabolized in the liver. Within 6 hours, 45% ~ 68% of the dose is excreted from the urine as the original drug, and some drugs are excreted by the biliary tract. This can be extended to 7 hours in patients with severe renal insufficiency. Hemodialysis can clear the product, but peritoneal dialysis can not clear the product.
Storage Block light and keep sealed.
FAQ 1.who are we? We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about50 people in our office.
2. how can we guarantee quality? Always a pre-production sample before mass production; Always final Inspection before shipment;
3.what can you buy from us? Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers? We haveour own manufacture factories andone professional sales team working for the clients all over the world.
5. what services can we provide? Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery; Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY; Accepted Payment Type: T/T,L/C,PayPal,Western Union; Language Spoken:English,Chinese,Japanese
Our Ddvantage: 1. Quick delivery 2. Online payment 3. Quality assurance 4. Welcome big order 5. After-sales service 24 hours 6. Competitive advantage products 7. Our value information is "Quality is our culture" 8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service a) Freeamples can be provided. b) Guide customers through professional technology and teach them how to use our products after sale c) Determine the lowest price of high-quality products 1.Skilledexperience: Our company is a leading manufacturer of professional production in Chinapharmaceutical field for manyyears. 2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you. 3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freightforwarder. 4. Fast delivery: We have stock, so once payment is received, we can deliver quickly. 5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours. 6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Complaint
