Complaint
| Sunitinib Chemical Properties |
| Melting point | 189-191°C |
| Boiling point | 572.1±50.0 °C(Predicted) |
| density | 1.2 |
| Fp | 299.8ºC |
| storage temp. | Sealed in dry,2-8°C |
| pka | 8.5(at 25ºC) |
| CAS DataBase Reference | 557795-19-4(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 24/25 |
| HS Code | 29337900 |
| Hazardous Substances Data | 557795-19-4(Hazardous Substances Data) |
| MSDS Information |
| Sunitinib Usage And Synthesis |
| Description | Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4-14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer. |
| Chemical Properties | Yellow Solid |
| Originator | Sugen (US) |
| Uses | A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic |
| Uses | Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
| Uses | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
| Uses | Labelled Sunitinib (S820000), a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). |
| Uses | Labelled Sunitinib, a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). |
| Brand name | (Pfizer). |
