Complaint
Ivermectin is a new type of broad-spectrum, high-efficiency, low-toxic antibiotic antiparasitic drug, which has a good repellent effect on internal and external parasites, especially nematodes and arthropods.
Ivermectin powder is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod, canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum drug resistant parasites.
Product Name | Ivermectin |
CAS | 70288-86-7 |
Einecs No | 274-536-0 |
Appearance | White crystalline powder |
MF | C48H74O14 |
Molecular Weight | 875.09 |
Purity | 99% |
Solubility | soluble in aceton, very slightly soluble in hot water and n-octanol, insoluble in cold water and methano. |
Shelf Life | 24 Months |
| ltems | Specifications | Results | ||
| Appearance | White or yellowish-white crystalline powder, slightly hygroscopic | Complies | ||
| Solubility | Practically insoluble in water, freely soluble in methylene chlorid, soluble in alcohol | Complies | ||
| ldentification | IR | Corresponds with that of CRS standard | Complies | |
| HPLC | The retention time for HzBla and HB1 in chromatogram obtained with the best solution corresponds to those of standard preparation | Complies | ||
| Appearance of solution | Clear and not more intensely colored than BYz | Complies | ||
| Specific optical rotation (anhydrous and solvent-free substance) | -20~-17° | -17.7° | ||
| Related substances(%) | Individual impurities(BRT1.3-1.5)2.5 | L-1:<0.05 K:2.1 | ||
| Any other impurities≤1 | c:0.05 A:0.58 J:0.21 H:0.31 D:0.05F:<0.05 E:0.53-2:0.17 RTS1,09:0.08 | |||
| Totals5 | 4 | |||
| Disregard limit:0.05 | ||||
| Ethanol and Formamide(%) | Ethanol<5.0 | 3.9 | ||
| Formamides3.0 | 2.6 | |||
| Heavy metal(%) | s0.002 | <0.002 | ||
| Water(%) | ≤1.0 | 0.14 | ||
| Catalyst(ugg) | S1 | <1 | ||
| Sulphated ash(%) | ≤0.1 | 0.05 | ||
| Assay(%) (HPLC, on dry basis) | HB13JH4aB1+H>B15) 290.9 | 98.1 | ||
| 95.gSHB4HB1a102.0 | 96 | |||
1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to oral semisynthetic broad-spectrum drug resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings
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