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Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl
Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl
Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl
Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl
Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl
Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl

Manufacturer Supply High quality/High cost performance CAS 65473-14-5 Naftifine Hydrochloride Naftifine HCl

Min.Order: 1
Product origin: Guangzhou, Guangdong, China
Infringement complaint: complaintComplaint
US$ 1 ~ 10

Description




 
Product nameNaftifine hydrochloride
CAS65473-14-5
Appearancewhite powder
Assay99%
StorageCool and Protect from light




Naftifine hydrochloride
Product Name Naftifine hydrochloride

CAS 65473-14-5

MF C21H22ClN

MW 323.86

EINECS 620-502-9

MOL File65473-14-5.mol

Chemical Properties

Melting point 172-175°C
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  ethanol: soluble50mg/mL
Merck  14,6355
CAS DataBase Reference 65473-14-5(CAS DataBase Reference)




Usage And Synthesis
Local antifungal agents

Naphthalennee hydrochloride, also known as cinnamonyl methylaminne, naphthalennee, and naphthalennee hydrochloride, is currently one of the commonly used drugs for fungal infection in Department of Dermatology, belonging to the local antifungal agents of acrylamines. It has bactericidal effect on the dermatophytes (Trichophyton, Microsporum and epidermis Trichophyton). It has bacteriostasis against Malassezia, Candida and other yeasts. It also has local bactericidal effect on Gram-positive and negative bacteria. The mechanism of its action is to inhibit the fungal squalene cyclooxygenase. It interferes with the biosynthesis of ergosterol in fungal cell wall. It affects the lipid metabolism of fungi and causes the damage or death of fungal cells to play a bactericidal and bacteriostasis effect. It is suitable for dermatophytosis caused by sensitive fungi, such as tinea corporis, tinea pedis, tinea capitis, onychomycosis, tinea versicolor, superficial candidiasis as well as erasing fungal disease in the skin folds. For the the external application of 1% Naftifine Hydrochloride Ointment on the skin by thehealthy people, about 3% to 6% of the doses can be absorbed.The concentration of naphthofinn on the surface of the skin at a single dose within 24 hours is sufficient to inhibit the growth of dermatitis. Naftifine can be converted to at least three metabolites through the oxidation of benzene ring and naphthalenne and N- alkylation in the body. About 40% to 60% of the drugs in the body are excreted in the form of the original and metabolite form into the urine, and the rest is excreted into the feces by the bile. The half-life of the skin external use of naftifine is about 2~3 days.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

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