| Uses | Gonad-stimulating principle. |
| Definition | ChEBI: A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. |
| Brand name | Lutrepulse (Ferring Pharmaceuticals). |
| Veterinary Drugs and Treatments | Go nadorelin is indicated (approved) for the treatment of ovarian follicular cysts in dairy cattle. Additionally, gona dorelin has been used in cattle to reduce the time interval from calving to first ovulation and to increase the number of ovulations within the first 3 months after calving. This may be particularly important in increasing fertility in cows with retained placenta.
In dogs, gonado relin has been used experimentally to help diagnose reproductive disorders or to identify intact animals versus castrated ones by maximally stimulating FSH and LH production. It has also been used experimentally in dogs to induce estrus through pulsatile dosing. While apparently effective, specialized administration equipment is required for this method.
Gona dorelin has been used in cats as an alternate therapy to FSH or hCG to induce estrus in cats with prolonged anestrus.
In Europe, a synthetic analogue bus erelin has been used in horses to stimulate cyclic estrus. Its efficacy rates poorly when compared to an artificial light program, however.
In human medicine, go nadorelin has been used for the diagnosis of hypothalamic-pituitary dysfunction, cryptorchidism, and depression secondary to prolonged severe stress. |
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