Rifampicin Capsules Used in Combination with Other Anti-Tuberculosis Drugs

Generic name: Rifampicin capsule
English name: Rifampicin Capsules
Chinese Pinyin: Lifuping Jiaonang
Ingredient
The main ingredient of this product is rifampicin
[Properties] This product is a capsule containing bright red or dark red crystalline powder.
1. This product is used in combination with other anti-tuberculosis drugs for the primary and secondary treatment of tuberculosis, including the treatment of tuberculous meningitis. 2. This product is used in combination with other drugs for the treatment of leprosy and non-tuberculous mycobacterium infection. 3. This product can be used in combination with vancomycin (IV) for severe infections caused by methicillin-resistant staphylococcus. The combined regimen of rifampicin and erythromycin is used for severe Legionella infections. 4. For asymptomatic Neisseria meningitidis carriers to eliminate Neisseria meningitidis in nasopharynx; But not for the treatment of Neisseria meningitidis infection.
[Usage and dosage] 1 Anti-tuberculosis treatment for adults: oral, 0.45g ~ 0.60g a day, taken on an empty stomach, no more than 1.2g a day; Children more than 1 month old daily according to the weight of 10 ~ 20mg/kg, fasting meal, the daily amount is not more than 0.6g.
2 Carriers of Neisseria meningititicus: adults 5mg/kg once every 12 hours for 2 consecutive days; Children over 1 month old 10mg/kg daily, once every 12 hours, four times in a row.
3 Elderly patients, oral, according to 10mg/kg per day, empty stomach.
[Adverse reactions] Chills, dizziness, fever, chills, loss of appetite, nausea and vomiting.
[Contraindication] 1. It is not allowed for those allergic to this product. 2. Patients with severe liver insufficiency are prohibited. 3 Patients with biliary obstruction were prohibited. 4 Pregnant women should not be allowed.
[Precautions] 1 Alcohol poisoning, liver function damage with caution. Use with caution for infants, pregnant women over 3 months and breastfeeding women. 2. Interference with diagnosis: it can lead to positive direct antiglobulin test (Coombs test); Interferes with the determination of serum folate concentration and serum vitamin B12 concentration; It can make the sulfonbromophthalide sodium test lingering false positive; Can interfere with the results of various urine analysis tests by spectrophotometer or colour change; It can increase the concentration of blood urea nitrogen, serum alkaline phosphatase, serum alanine aminotransferase, aspartate aminotransferase, serum bilirubin and serum uric acid. 3 rifampicin can cause liver function is not complete, the original liver disease or this product with other drug hepatotoxicity suits with jaundice deaths reported from time to tome, so the original liver disease patients, only under the condition with clear indications can be careful, before the start of treatment, treatment, close observation of liver function change, liver damage once appear, immediately. 4 Hyperbilirubinemia is a combination of hepatocellular and bile retention, which resolves spontaneously in mild cases, and should be discontinued for severe cases. Elevated blood bilirubin may also be the result of rifampicin competing with bilirubin for excretion. The changes of liver function should be closely monitored during the first 2 to 3 months of treatment. 5 Rifampicin alone in the treatment of tuberculosis or other bacterial infections can rapidly develop resistance to the pathogen, so this product must be used in combination with other drugs. Treatment may last six months to two years, or even years. 6 Rifampicin may cause leukocyte and platelet reduction, and lead to gingival bleeding and infection, delayed wound healing, etc. At this time, tooth extraction and other operations should be avoided, and pay attention to oral hygiene, brushing and picking teeth should be careful until the blood image returns to normal. Peripheral blood images should be checked regularly during medication. 7 Rifampicin should be taken one hour before or two hours after a meal. The best absorption is taken once on an empty stomach in the morning, because eating affects the absorption of this product. 8. Reduced dose, daily dose, is often required in patients with liver dysfunction. 8 mg/kg. There is no need to reduce the amount of renal function. The serum concentration of rifampicin did not change significantly in patients with reduced glomerular filtration rate or no urine. 10 After taking the medicine, urine, saliva, sweat and other excrement can be orange.
[Medication for Special groups] Precautions for Children:
The safety of this product for use in children under 5 years of age has not been established.

Precautions during pregnancy and lactation:
1. Rifampicin can transgress the placenta and has caused teratogenesis in animal experiments. Human beings is
No teratogenesis has been reported, but there is insufficient data to indicate safe use during pregnancy.
2. Rifampicin can be excreted by milk, and the benefits should be fully weighed for lactating women
Decide whether or not to take medication.

Notes for the elderly:
The liver function of elderly patients has decreased, the dosage should be reduced.
[Drug interaction] 1 Taking rifampicin and drinking alcohol daily can increase the incidence of rifampicin hepatotoxicity and increase the metabolism of rifampicin. Therefore, it is necessary to adjust the dose of rifampicin and closely monitor patients for signs of hepatotoxicity. 2 adrenal cortical hormone (glucocorticoids, mineralocorticoid), anticoagulants, coumarin, or indan diketone derivatives, fall blood sugar medicine oral, corticotrophin, dapsone, digitalis glycosides, c pyrazole amine, quinidine and rifampicin used, because the latter on the stimulating effect of the liver microsomal enzymes, can make the efficacy of these drugs reduce, so in addition to the digoxin and dapsone, The dosage of these drugs should be adjusted before and during the treatment of rifampicin. When this product is combined with coumarin or ninhydrin, the thrombin time should be measured daily or periodically to adjust the dose. 3 p - amino salicylate can affect the absorption of rifampicin and lead to the decrease of rifampicin concentration. Patients were given paraminosalicylate and rifampin at least 6 hours apart. 4 Rifampicin can stimulate the metabolism of estrogen or reduce its intestinal liver circulation, reduce the effect of oral contraceptives, lead to irregular menstruation, intermenstrual bleeding and unplanned pregnancy, patients taking rifampicin, should use other contraceptive methods. 5. Rifampicin can induce liver microsomal enzyme, increase the metabolism of anti-tumor drugs dacarbazine and cyclophosphamide, form alkylated metabolites, and promote the reduction of white blood cells, so the dose needs to be adjusted. The combination of isoniazid with rifampicin or miconazole (IV) and ketoconazole increases the risk of hepatotoxicity, especially in patients with pre-existing liver function impairment and isoniazid rapid acetylation. In addition, the combination of isoniazid or rifampicin with miconazole or ketoconazole can reduce the blood concentrations of the latter two. Therefore, this product and isoniazid should not be used with imidazoles. 7 The combination of rifampicin and diazepam (diazepam) can increase the elimination of the latter and reduce its blood concentration, so the dose needs to be adjusted. The combination of rifampicin and ethoinicotinamine can aggravate the adverse reactions. 9 Rifampicin can increase the degradation of levothyroxine in the liver, so the dose of levothyroxine should be increased when the two are used together. Rifampicin can also increase the metabolism of methadone and methadone in the liver, causing methadone withdrawal symptoms and methadone reduction in blood concentration, so the dose of the latter two should be adjusted when used together. Rifampicin can increase the metabolism of phenytoin sodium in liver, so the concentration of phenytoin sodium should be measured and the dosage should be adjusted when the two are used together. 10 Presulfa can compete with rifampicin to be ingested by liver cells, which increases the blood concentration of rifampicin and produces toxic reactions. But the action is not stable, so it is usually not appropriate to add two sulfoshu to increase the blood concentration of rifampicin.
Pharmacological effects Each pill contains 0.15g of rifampicin, and the contents are orange-red or dark red powder. Rifampicin is a semi-synthetic broad - spectrum fungicide. This product is used in combination with other anti-tuberculosis drugs for the primary and secondary treatment of tuberculosis. It is also indicated for asymptomatic meningococcal carriers to eliminate the nasopharyngeal Neptinitis meningococcal bacteria (not for the treatment of meningococcal infections). Rifampicin may also be considered for the prevention of infection in persons exposed to influenza bacilli; Combined with other drugs for the treatment of leprosy, atypical mycobacterium infection.
Storage: Seal and store in a dark and dry place.
Specification 0.15g
[Validity period] 24 months.



FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


Factory View


Our Products


Our Business