Description
Vitamin K1(Phytomenadione)CAS:84-80-0
Vitamin K1, also known as plant menadione, chlorophyllin menadione and chlorophyllin quinone, is a polycyclic aromatic ketone and a fat soluble vitamin, which is widely found in natural green plants and can be decomposed in the sun.Vitamin K1 is a vitamin drug, which is necessary for liver synthesis factors II, VII, IX and X. It is mainly used for the treatment of various hemorrhagic diseases caused by vitamin K deficiency, which can promote blood coagulation, promote the synthesis of prothrombin in the liver, and increase intestinal peristalsis and secretion.Item | Specification | Result |
Characteristics | Clear intense yellow, viscous, oily liquid; Practically insoluble in water, sparingly soluble in alcohol(96%), miscible with fatty oils. It decomposes on exposure to actinic light. | Conforms |
Trans-phytomenadione | 75.0% Min. | 88.1% |
Trans-epoxyphytomenadione | 4.0% Max | 0.05% |
Sum of trans-phytomenadione, cis-phytomenadione and trans-expoxyphytomenadione | 97.0% to 103% | 100.1% |
Refractive Index | About 1.526 | 1.526 |
Identification | - Ultraviolet and visible absorption spectrophotometry
- Examine the chromatograms obtained in the assay
- Dissolve 50mg in 10ml of meth anol R and add
- 1 ml of a 200g/l solution of potassium -hydroxide R in meth anol R. A green color is produced which becomes violet-red on heating in a water bath at 40ºC and then reddish-brown on standing.
| Conforms |
Appearance of solution | Dissolve 2.5g in trimethylpentane R and dilute to 25ml with the same solvent. The solution is clear. | Conforms |
Acid value | 2.0 max, determined on 2.00g | 0.08 |
Impurity (Menadione) | As per EP IX | Conforms |
Related substances | As per EP IX | Conforms |
Sulphated ash | 0.1% max. determined on 1.0g | Conforms |
Storage | Protected from light | Conforms |
Reference standard | EP IX | Conforms |
Vitamin K1 is a kind of vitamin medicine, mainly used in medicine:
- It is necessary for liver to combine prothrombin II, VII, IX and X. Vitamin k1 deficiency can lead to disorder or abnormality of thrombin synthesis.
- Vitamin k1 can also relieve pain and spasm. It has obvious curative effect on angina pectoris of undivided splanchnic muscle, colic of catheter and colic of intestine.
- High dose of vitamin K1 can promote the survival of liver cells and enhance the phagocytosis of mononuclear macrophages, so it has a certain effect on chronic hepatitis.
- It is widely used for clinical bleeding caused by lack of vitamin k1, such as obstructive jaundice, bile fistula, and chronic diarrhea; Hypoprothrombin Hyperlipidemia Induced by Coumarin and Sodium Salicylate
- Long term use of broad-spectrum antibiotics leads to neonatal hemorrhage and vitamin k1 deficiency.
- As a nutrient enhancer, it is widely used in the production of multi vitamin food and livestock feed
10tins X 1kg/tin in 1 carton;
2tins X 5kgs/tin in 1 carton;
4tins X 5kgs/tin in 1 carton.
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SCM was established by group of experts who have more than ten years experiences in pharmaceutical and food ingredients industries. with our deep knowledge and diligence, together with our associated plants, we would like to provide one-stop sourcing solutions for customers, to save your time and secure your purchasing.
1.Which filed can be used of Vitamin K1?
Vitamin K1 is a vitamin drug, which is mainly used for the treatment of various hemorrhagic diseases caused by vitamin K deficiency, that can promote blood coagulation, promote the synthesis of prothrombin in the liver, and increase intestinal peristalsis and secretion.
2.Any quality standard of the Vitamin K1?
Quality standard: EP, USP.
3.Can I get some sample for test?
Sure, we can supply samples free for your test. Normally 20g is enough.
4.How can you guarantee the quality?
We cooperate with factory with following standard: Natural product fermented from Saccharomyces cerevisiae. GMP, KFDA, DCGI, Kosher, halal and HACCP certificates.
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