Plant Origin: Citrus Aurantium
Part Used: Fruit
Specification: Synephrine 6%,10%,30%,80%,95% by HPLC, Citrus Bioflavones 60% by HPLC, Citrus Bioflavones 15% by UV
CAS No.: 94-07-5
Molecular Formula: C9H13NO2
Molecular Weight: 167.2
Melting Point: 187ºC
1. Weight Loss
The most likely explanation for weight loss effects attributed to citrus aurantium supplements is the amphetamine-like effects of the alkaloids. Although this effect is likely to be somewhat less dramatic than effects induced by Ma Huang (ephedra alkaloids), users can expect variable effects including enhanced caloric expenditure, reduced appetite and heightened feelings of energy, all of which are likely to result in weight loss. A recent study conducted in dogs also suggests that synephrine can increase metabolic rate in a specific type of fat tissue known as Brown Adipose Tissue (BAT).
Since synephrine and several other compounds found in zhi shi are structurally and act as stimulants to specific adrenergic receptors (beta-3, but not beta-1, beta-2 or alpha-1), zhi shi does not appear to have the same negative central nervous effects of Ma Huang (ephedra), which stimulates all beta-adrenergic receptors.
2. Mild Exhilarant
Studies have attributed the energy enhancing effect of synephrine to stimulation of the Centre Nervous System. This integrated effect may include increased circulation of blood through the heart and cerebral tissue, elevated blood pressure and improved mental activity, which would readily qualify synephrine as a mild exhilarant.
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