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KX-826 is a new investigational androgen receptor (AR) antagonist for the treatment of male pattern hair loss (androgenetic alopecia). A total of 120 subjects will be randomized to one of four cohorts: 2.5 mg BID, 5 mg QD, 5mg BID of KX-826 or placebo (BID or QD) for 24 weeks. The primary endpoint of the study is to assess the changes from baseline in non-vellus TAHC (Target Area Hair Counts)at Week 24 in comparison to placebo.
Pyrilutamide, also known as KX-826, is a non-steroidal anti-androgen that works by blocking androgens such as testos one and DHT from binding with the androgen receptor. It was developed by a biotech company called Kintor Pharmaceuticals.
| Product name | KX826 |
| CAS No. | \ |
| Molecular Formula | C21H15F5N4O2S |
| Molecular weight | 482.43 |
| EINECS NO. | N/A |
| Grade Standard | pharmacy grade |
| COA | available |
Pyrilutamide (developmental code name KX-826) is a nonsteroidal antiandrogen (NSAA) - specifically, a selective high-affinity antagonist of the androgen receptor (AR). It has a high affinity of IC50 of 0.28nM, with the androgen receptor.
Pyrilutamide inhibits the signaling pathway mediated by androgens and their receptors locally, and finasteride systemically inhibits androgens by competing with androgens in the target organizer for binding to androgen receptors. Different from DHT synthesis to stimulate hair growth, this mechanism avoids the reduction of systemic androgen levels and the resulting clinical side effects while blocking the signal transmission to stimulate hair growth.
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