Good Quality Cetilistat Powder CAS 282526-98-1

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Product origin: Jinan, Shandong, China

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US$ 200 ~ 400

Description

Good Quality Cetilistat Powder
CAS 282526-98-1

Cetislim containing the active ingredient cetilistat is considered a lipase inhibitor type of medication. The medication works by blocking the metabolization of fat within food so you do not digest it and the undigested fat will be passed through the body in bowel movement. The capsules should be used along with a low calorie, low fat diet and a proper exercise program to treat obesity. Reducing calorie intake and weight maintenance can help prevent and treat conditions such as high cholesterol, diabetes, hypertension and heart disease.

Product Name	Cetilistat
Synonyms	ATL-962, Cetilistat
CAS	282526-98-1
MW	401.58
EINECS	1308068-626-2

Cetilistat Chemical Properties

Melting point	72.0 to 76.0 °C
Boiling point	509.7±43.0 °C(Predicted)
density	1.02
pka	2.96±0.20(Predicted)
InChIKey	MVCQKIKWYUURMU-UHFFFAOYSA-N
CAS DataBase Reference	282526-98-1(CAS DataBase Reference)

Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m2 in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. The synthesis of cetilistat involves condensation of a hexadecylcarbonochloridate with 2-amino-5-methylbenzoic acid; other analogs were synthesized by varying the carbonochloridate and 2-aminobenzoic acid components. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin.

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