Complaint
Vitamin B12 Injection
Composition:
Each 2ml ampoule contains cyanocobalamin (Vitamin B12) USP 1000mcg or 2000mcg. Vitamin BI2 Injection is a sterile solution of Cyanocobalamin in water for Injections containing. This agent is pinkish to red supernatant light
Action:
Vitamin B12 water -solution vitamin, occurs in the body mainly as methyleohydroxocobabmin (TnecobailEimm) and as adenosylcobalamin (eobamamide) and hydroxocobalamin. Mecobalamin and eobamamide act as coenzymes in nucleic acid synthesis. Mecobalamin is also closcly involved with folic acid in several important metabotic pathways.
Indication:
Vitamin B12 plays an important role in the formation of red blood cells, for neurological health and the production of DNA. B12 injections are available with a doctor's prescription and indicated for people who cannot maintain diet-bound blood serum levels of B12. Foods rich in B12 include beef liver, clams and fortified cereal and milk. Anemia, fatigue, weakness, weight loss and loss of appetite are a few of the symptoms of a B12 deficiency.
Adverse Effects:
Vitamin B12 has extremely low toxicity, and even taking enormous doses does not appear to be harmful to healthy individuals.
Hematologic:
Peripheral vascular thrombosis has been reported. Treatment of vitamin B12 deficiency can unmask polycythemia vera, which is characterized by an increase in blood volume and the number of red blood cells. The correction ofmegaloblastic anemia with vitamin B12 can result in fatal hypokalemia and gout in susceptible individuals, and it can obscure folate deficiency in megaloblastic anemia.
Leber's disease: Vitamin B12 in the form of cyanocobalamin is contraindicated in early Leber's disease, which is hereditary optic nerve atrophy. Cyanocobalamin can cause severe and swift optic atrophy, but other forms of vitamin B12 are available. However, the sources of this statement are not clear, while an opposing view concludes: "The clinical picture of optic neuropathy associated with vitamin B12 deficiency shows similarity to that of Leber's disease optic neuropathy. Both involve the nerve fibers of the papillomacular bundle. The present case reports suggest that optic neuropathy in patients carrying a primary LHON mtDNA mutation may be precipitated by vitamin B12 deficiency. Therefore, known carriers should take care to have an adequate dietary intake of vitamin B12 and malabsorption syndromes like those occurring in familial pernicious anaemia or after gastric surgery should be excluded."
Precautions & Warning:
Before using cyanocobalamin, tell your doctor or pharmacist if you are allergic to it; or to cobalt; or if you have any other allergies. Your doctor may recommend that you receive a smaller test dose before starting your regular dose. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: low potassium blood levels (hypokalemia), gout, a certain blood disorder (polycythemia vera), a certain eye disease (Leber's disease), other vitamin/mineral deficiencies (especially folic acid and iron).
This product may contain aluminum, which can infrequently build up to dangerous levels in the body. The risk may be increased if this product is used for an extended time, especially in newborns or in people with kidney disease. Tell your doctor immediately if you notice any symptoms of too much aluminum in the body such as muscle weakness, bone pain, or mental changes.
Storage:
Store below 25ºC in well- closed containers. Protect from light. Keep out of reach of children.
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