Complaint
Oxytocin
| Product Name | Oxytocin Acetate |
| Cas No. | 50-56-6 |
| Molecular Formula | C43H66N12O12S2 |
| Molecular Weight | 1007.2 |
| Purity (HPAppearanceLC) | 98.0%min. |
| Appearance | White powder |
| Single Impurity(HPLC) | 1.0%max |
| Amino Acid Composition | ±10% of theoretical |
| Peptide Content(N%) | ≥80.0% |
| Water Content(Karl Fischer) | ≤6.0% |
| Acetate Content(HPIC) | ≤12.0% |
| Mass Balance | 95.0~105.0% |
| MS(ESI) | Consistent |
2.Description:
Oxytocin (Oxt) is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain.
Oxytocin plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth; its name, meaning "swift childbirth", comes from Greek, oksys "swift" and , tokos "birth." It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms.
4.Usage and dosage:
Odinopoeia or oxytocin intravenous drip, once the 2.5 - 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 - 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 - 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 - 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.
Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.
The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.
