Complaint
| GUANGZHOU KIAS BIOTECHNOLOGY CO,LTD | |
| Product Name | Tetracaine Hydrochloride |
| Synonyms: | LANDOCAINHYDROCHLORIDE;INTERCAINHYDROCHLORIDE;MEETHOBALMHYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOICACID2-(DIMETHYLAMINO)ETHYLESTERHYDROCHLORIDE;4-[BUTYLAMINO]BENZOICACID-2-[DIChemicalbookMETHYLAMINO]ETHYLESTERHYDROCHLORIDE;4-BUTYLAMINOBENZOICACIDDIMETHYLAMINOETHYLESTERHCL;4-BUTYLAMINOBENZOICACIDDIMETHYLAMINOETHYLESTERHYDROCHLORIDE;AMETHOCAINEHYDROCHLORIDE |
| CAS: | 136-47-0 |
| MF: | C15H25ClN2O2 |
| MW: | 264.36 |
| EINECS: | 205-248-5 |
| Product Categories: | research chemical;Active Pharmaceutical Ingredients |
| Melting point | 149°C |
| Boiling point | 389.4°C at 760 mmHg |
| density | 1.1279 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Water Solubility | Soluble in water at 50mg/ml |
| Uses | Anesthetic (local). |
What is Tetracaine Hydrochloride ?
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxid.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
What is the difference between the anesthetic intensity of tetracaine hydrochloride powder and lidocaine, procaine ?
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene | confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. | confirm |
| Melting point | 145~150 degree | 146.0~147.5 degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | ≤10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | ≤0.10% | 0.05% |
| Loss on Drying | ≤ 0.5% | 0.19% |
| Assay | 98.0 -101.0% | 99.9% |
| Conclusion | Confirms USP 32 | |
| CN | CAS. NO | Name |
| 1 | 23239-88-5 | Benzocaine Hydrochloride |
| 2 | 94-09-7 | Benzocaine |
| 3 | 51-05-8 | Procaine Hydrochloride |
| 4 | 59-46-1 | Procaine |
| 5 | 14769-73-4 | Levamisole |
| 6 | 137-58-6 | Lidocaine |
| 7 | 73-78-9 | Lidocaine Hydrochloride |
| 8 | 94-24-6 | Tetracaine |
| 9 | 136-47-0 | Tetracaine Hydrochloride |
| 11 | 132112-35-7 | Ropivacaine Hydrochloride |
| 12 | 61-12-1 | Dibucaine Hydrochloride |
| 13 | 2180-92-9 | Bupivacaine |
| 14 | 14252-80-3 | Bupivacaine Hydrochloride |
| 15 | 536-43-6 | Dyclonine Hydrochloride |
| 16 | 6130-64-9 | Procaine penicillin |
| 17 | 23964-57-0 | Articaine Hydrochloride |
| 18 | 637-58-1 | Pramoxine Hydrochloride |
| 19 | 27262-48-2 | Levobupivacaine Hydrochloride |
| 20 | 751-50-6 | Prilocaine Base |
| 21 | 1786-81-8 | Propitocaine Hydrochloride |
| 22 | 5875-06-9 | Proparacaine Hydrochloride |
| 23 | 614-39-1 | Procainamide Hydrochloride |
| 24 | 5086-74-8 | Tetramisole Hydrochloride |
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We are a professional manufacturer of chemical raw materials, We specialize in this filed for many years,Standard bp/usp/ep/enterprise standard.All purity>99%.Great quality,High purity and favorable,Good quality is one of our biggest secret to success;u can get the best quality and service from us.
