Complaint
| Name | OTESALY | Treatment area | Dynamic wrinkles, wrinkles due to movement | |
| Specifications | 50iu,100iu, 150iu | Duration | 4 to 6 months | |
| Composition | betulinumtoxin type A | Shelf life | 3 years | |
| Function | removing facial wrinkles | Storage | Freeze-dried products in -20 ºC can be kept for 3 years , in 2-8 ºC ,then 2 years, in 25 ºC ,7-10 days |
Dilution method:
1 Remove drugs from the refrigerator when you decide the treatment.
2 After taking it out , put at room temperature for a certain time, usually 10-15min, in order to be similar as the room temperature,then easy to dilute.
3. Generally diluted 100iu.with 2-4ML normal saline solution .
4. when dilution, you should stick the bottle wall safety with the syringe needle, then push the Normal saline into bottle slowly to avoid air bubbles, make all the powder drugs dissolved, Don't use excessive force. Otherwise ,it will affect the drug action.
5. In the melting process, avoid repeated suction to reduce vibration and prevent bubble formation, bubble will make protein denaturation ,which can affect drug action.
6, configured solution should be used immediately or placed in refrigerator 2-8 ºC, 4h in good condition, no more than 6h, if keep too long ,will reduced efficacy. After 12h it will be 44% inactivation ,1-2week, 70% inactivation .
7 BTXA injection should be sufficient quantity one time , injection intervals must be more than 3 months. BTXA is protein, if low-dose, short interval will be easy to form antibody which make a small effect, even invalid.
Injection Tips:
In order to reduce the complication of blepharoptosis:
(1)Avoid injection near the levator ,palpebrae superioris, particularly in patients with larger brow-depressor complexes
(2)Medial corrugators injections should be placed at least 1 cm above the bony supraorbital ridge
(3) usage dose
It is about 25 iu best for Cosmetic injection ,not more than 60iu.
(4) It is the best 0.1ML (2.5-5 iu ) for each injected point. 4-8 points is preferred.
Storage and Transportation:
2. Therefore, If the BTXA is packed with dry ice or Jelly ice during transport, BTXA will not lose the effect for 7-10days.
Package
1, with ice packs to keep cold.
2, 10 boxes of products delivered in a hard carton.
Out packing specification(1piece):34*33*18cm
3, 21boxes of products delivered in a hard carton.
Out packing specification(1piece): 34*33*35cm
Shipping
by air, delivery will be made within 2 working days after payment. Storage: Protect from light source. Do not use after the Expiration date. Store for two years.
About AOMA CO., LTD.
1, Main Products
We are a professional manufacturer engaged in the research, development, production, export and service of OTESALY dermal fillers and mesotherapy solution products for skin rejuvenation, skin whitening, hair growth and lipolysis; SOMED dermal fillers; JEALIFILL dermal fillers.
2, Trademark
OTESALY brand is registered in Europe, USA, Kazakhstan, Iraq, Russia, Colombia, Mexico, Brazil, Venezuela, Ecuador, Serbia...
3, CE(NB 2764) & ISO 13485 Certificate
AOMA CO., LTD. import the FDA & Europe EDQM approved raw material of Medical Sodium Hyaluronate Gel which costs around 45,000USD/kg from USA. More than 4 million people worldwide have been used AOMA CO.,LTD products so far. 96% of customers buy again after tried AOMA CO., LTD. products.
4, OEM & ODM available.
OEM and ODM services are available according to customers' specified requirements. Our professional production team & designing team are always there to help you for creating your branded products of dermal fillers & mesotherapy solution products without charging any extra designing fee.
5, 17 Years History
AOMA CO., LTD was established in 2005, started export medical products since 2006 and has sold products on Made in China website since 2007. We are verified supplier on Alibaba for more than 12 years with good reputation.
6, GMP Workshop
Our factory covers an area of 4,800 square meters, 3 production lines, founded with 800 square meters, 10,000 class purification workshop and 300 square meters 100 class purification workshop. The production area is about 3,200 square meters. We have a terminal sterilization technology and strict quality control system. The sodium hyaluronate gel is sterilized by high pressure steam, and the needle is sterilized by gamma rays. The preparation is aseptic and pyrogen-free, which ensure the safety and high quality of the products without pollution.
7, Top Production Equipments
We have the most advanced production equipment imported from European countries, such as automatic vacuum filling and stoppering machine from Germany OPTIMA, two-door cabinet type sterilizer from Sweden GETINGE, Agilent HPLC, UV, Shimadzu GC, Malvern rheometer, etc.
8, Strict Clinical Test
We entered the clinical test from 2006, and cooperates with medical institutions such as The First Affiliated Hospital of Zhejiang University, Shanghai Ninth People's Hospital, etc. The results show that our cross-linked sodium hyaluronate gel for plastic surgery can meet the clinical needs, the quality of the prepared products is stable, the filling effect is good, the maintenance time is long, and the rate of adverse reactions is low.
Guangzhou Aoma International Co LTD is a hi-tech corporation integrating with manufacture and trading, founded in 1992. Our company has been engaged in developing and producing medical and aesthetic correction products with registered brand OTESALY for more than 10 years. We had passed ISO, GMP, MSDS certification.Our factory covers about 80000 square meters,founded with 1000 square meters C class purification workshops, 200 square meters B class clean rooms.
With technique innovation we gradually become an expert in this field. Complied with the quality management system ISO 9001:2000, medical sodium Hyaluronate injectable gel were began to market. Our main products are hyaluronic acid filler, Betulinum toxin type A, mesotherapy solution with different formula, like lipolytic, anti-hair loss, skin whitening and skin Rejuvenating,dermal roller, bio-fiber mask etc. Our expertise and experience in biotechnology give us capability of developing various cosmeceutical products with high quality. From raw materials to finished products we provide what customer needs and wants.
Why choose us?
We have the first class quality while the price is pretty reasonable, because we want to popularize our products .
Our raw material is medical grade HA from American FDA and Europe EDQM. Our glass syringes and needles are made by B&D company. The rotation of 360 ° allows more precision and comfortable during the application. The plastic box material is PET, made by Du Pont, which is the only one of the FDA certificate in the world. It matches perfectly the medical devices packaging requirements.
Our factory covers about 8000 square meters,founded with 1000 square meters C class purification workshops, 200 square meters B class clean rooms. We made our products more safe and stable with the aseptic processing technique, equipped with 100 grade side by side combination oven, side by side autoclave cabinet, full-automatic aseptic canning equipment and prefilled terminal aseptic equipment.
Our service:
We provide OEM and ODM service:
(1).Software adjustment (logo & menu design, different languages)
(2).Unique package shape design
(3).Treatment handle, filters design.
(4).Package (style, material, label design)
1.How does BTXA work?
Normally, your brain sends electrochemical messages to your muscles to make them contract and move. These messages are transmitted from a nerve to the muscle by a substance called acetylcholine. When too much acetylcholine is released, muscles become overly active and spasm or tense up. BTXA blocks the nerve from releasing acetylcholine. As a result, the muscle spasms stop or are greatly reduced, providing relief from symptoms.(In a word, the function of BTXA is to stop the signals of moving this muscle from your brain, to keep smooth on the skin surface, so it helps decrease some fine lines.)
Your health care provider will know how much BTXA is needed to treat you effectively.
It's important to remember that boltulinum toxin treatment is not a cure. For many people, however, its effects have been dramatic. With BTXA, the nerve will take about 3 months to recover and begin to release acetylcholine, and the muscles may become overactive again. At that point, another injection will be needed to provide relief, as long as no allergic reactions or other significant side effects occurred and clinical response was obtained.
2.How Long can I be treated with BTXA ?
(Each treatment typically lasts up to 3 months and can be repeated as long as your condition responds to BTXA and you do not have any serious allergic reactions or other significant side effects. BTXA has been used for more than 11 years to treat more than 1 million patients worldwide, and although formal, long-term clinical evaluations have not been conducted, its safety in long-term use has been well established.
Although most people continue to respond to BTXA injections, some people have experienced a diminished response over time. There may be several explanations for this:
• Changes in your condition - If the pattern of your muscle activity changes, your health care provider may need to inject new muscles and/or change your dose. Identifying and injecting the affected muscle can be difficult, complicated by the changing pattern of muscle involvement and progression of the disorder.
• Setting appropriate expectations - You may believe your first BTXA injection was more helpful than subsequent injections. That's because your condition was perhaps quite severe when you had your first injection. Subsequent injections are usually given before your condition becomes that severe again. Therefore, the relief you experienced with subsequent injections may not have been as dramatic as the first time.
• Antibody formation - When foreign proteins, like betulinum toxins, enter your body, antibodies may form. If antibodies to betulinum toxin develop, you may no longer respond to treatment.
Because boltulinum toxins are usually used to treat chronic conditions, it's important to preserve responsiveness to therapy.
3.How can I help maintain my response to BTXA ?
While the critical factors for neutralizing antibody formation have not been well characterized, you may be able to help maintain your response to BTXA by minimizing your total exposure. The potential for antibody formation may be minimized by injecting with the lowest effective dose given at the longest feasible intervals between injections
4.How is BTXA given?
BTXA is injected into the affected muscle(s). Your doctor will determine which muscles need to be treated.
5.Does the injection hurt?
Some people report minor, temporary discomfort from the injection. BTXA is reconstituted with sterile, preservative-free normal saline for injection. The neutral pH of the injected solution, in combination with the fine-gauge needle your doctor will use, can help to minimize any injection-related pain.
6.When will BTXA start to work?
If you're receiving BTXA for cervical dystonia, you'll usually see the effects within 2 weeks of the injection. If you're receiving BTXA for blepharospasm, you'll usually see effects within 3 days.
Initial effect is different in different injection location on different body. Normally it is around 1 week.
7.How Long will the effect last?
BTXA offers sustained relief, dose after dose. The relief you'll feel from one treatment of BTXA will normally last for up to 6-12 months. Treatments can be continued as long as your condition responds to BTXA, and you do not have any serious allergic reactions or other significant side effects. When the relief begins to fade, you'll return to your doctor for your next treatment.
Usually, BTXA treatment is required approximately four times per year. Because symptoms can change over time, the amount and duration of relief you'll experience can vary. Consult your doctor, who can determine how to achieve the best possible results with BTXA
8.Is BTXA right for me?
Your health care provider can help you decide if BTXA is right for you. In order to make the right treatment decision, you should discuss the following with your health care provider before choosing treatment:
• Clinical experience with the drug
• Effectiveness and side effects
Make sure your health care provider knows if you are pregnant, nursing, or taking any medications before receiving BTXA injections. Additionally, you should not receive BTXA if you have an infection at the injection site.
BTXA should be used with caution if you have other neurological diseases or disorders, or if you are taking amino glycoside antibiotics or other drugs that interfere with neuromuscular transmission. Be sure to tell your health care provider about any prescription or over-the-counter medications you are taking before receiving BTXA.
