Complaint
Action:
Vilamin B12 water -solution vitamin, occurs in the body mainly as methyleohydroxocobabmin (TnecobailEimm) and as adenosylcobalamin (eobamamide) and hydroxocobalamin. Mecobalamin and eobamamide act as coenzymes in nucleic acid synthesis. Mecobalamin is also closcly involved with folic acid in several important metabotic pathways.
Indication:
Vitamin B12 plays an important role in the formation of red blood cells, for neurological health and the production of DNA. B12 injections are available with a doctor's prescription and indicated for people who cannot maintain diet-bound blood serum levels of B12. Foods rich in B12 include beef liver, clams and fortified cereal and milk. Anemia, fatigue, weakness, weight loss and loss of appetite are a few of the symptoms of a B12 deficiency.
Adverse Effects:
Vitamin B12 has extremely low toxicity, and even taking enormous doses does not appear to be harmful to healthy individuals.
Hematologic:
Peripheral vascular thrombosis has been reported. Treatment of vitamin B12 deficiency can unmask polycythemia vera, which is characterized by an increase in blood volume and the number of red blood cells. The correction of megaloblastic anemia with vitamin B12 can result in fatal hypokalemia and gout in susceptible individuals, and it can obscure folate deficiency in megaloblastic anemia.
Leber's disease: Vitamin B12 in the form of cyanocobalamin is contraindicated in early Leber's disease, which is hereditary optic nerve atrophy. Cyanocobalamin can cause severe and swift optic atrophy, but other forms of vitamin B12 are available. However, the sources of this statement are not clear, while an opposing view concludes: "The clinical picture of optic neuropathy associated with vitamin B12 deficiency shows similarity to that of Leber's disease optic neuropathy. Both involve the nerve fibers of the papillomacular bundle. The present case reports suggest that optic neuropathy in patients carrying a primary LHON mtDNA mutation may be precipitated by vitamin B12 deficiency. Therefore, known carriers should take care to have an adequate dietary intake of vitamin B12 and malabsorption syndromes like those occurring in familial pernicious anaemia or after gastric surgery should be excluded."
