Complaint
OMPOSITION
2mg loperamide hydrochloride per capsule
PHARMACOLOGICAL CLASSIFICATION
Medicines acting on gastro-intestinal tract. Antidiarrhoeals.
PHARMACOLOGICALACTION
PERATOR CAPS inhibits hypermotility by direct action on the bowel wall. Its inhibition of peristalsis is the result of decreasing the activity of both the longitudinal museles (preparatory and reflex phases) and the circular muscles (reflex phase).
PERATOR CAPS normalizes the stool in both acute and chronic diarrhoea.
PERATOR CAPS is incompletely absorbed from the gut, and it is almost completely metabolized in the liver where it is conjugated and excreted via the bile.
PERATOR CAPS is mainly eliminated via the faeces.
INDICATIONS
Adults and children 6 years and older: PERATOR CAPS is indicated for the control and symptomatic relief of acute and chronic nonspecific diarrhoea and inhibition of peristalsis and slowing of intestinal transit time in patients with ileostomies, colostomies and other intestinal resections.
Children below 6 years of age: PERATOR CAPS is indicated for inhibition of peristalsis and slowing intestinal transit time.
CONTRA-INDICATIONS
PERATOR CAPS is contra-indicated in patients with a known hypersensitivity to the medicine.
PERATOR CAPS is contra-indicated in infants under 24 months of age.
Since treatment of diarrhoea with PERATOR CAPS is only symptomatic, diarrhoea should be treated causally, whenever causal treatment is available. PERATOR CAPS should not be used as the primary therapy in acute dysentery, which is characterised by blood in stools and high fever. PERATOR CAPS must not be used in patients with acute ulcerative colitis or pseudomembranous colitis associated with broad-spectrum antibiotics. In general, PERATOR CAPS should not be used when inhibition of peristalsis is to be avoided and must be discontinued promptly if constipation, abdominal distension or subileus develop. Loperamide administration may precipitate toxic megacolon in patients with inflammatory bowel disease.
The safety of use during pregnancy and lactation has not been established.
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