Complaint
Chemical Name: 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (A-ICAR for short)
Also Known as ACADESINE.
CAS: 2627-69-2
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
EINECS: 220-097-5
Melting point : 214-215 °C
Appearance: Off-White Powder .
A-ICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that A-ICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that A-ICAR can mimic the activity of insul (sc-211647) by activating AM PK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). A-ICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
(AM PK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.A-ICAR is a selective activator of AM PK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.A-ICAR (0.5 mM) inhibits insul-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
Wuhan Vanz Pharm Inc.
Our Company was founded in 2011 and We are comprehensive enterprise with business range covering R&D, production and sales of APIs, pharmaceutical intermediates, plant extracts, all kinds of organic intermediates and so on. We bought 14,000 square meters production base in Panhu Industrial Park, established several pharmaceutical synthesis production lines, and continually expands our production capacity.
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A: Yes, we can supply the sample, but the sample is chargeable and the shipping cost should also be paid by our customers. Please kindly understand we do have production cost on samples. We will not charge you high but it has valuewhich need to be paid.
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If you need further confirmation, you can buy some samples, this is the most direct way.
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