Complaint
| ITEMS | SPECIFICATION | RESULTS | |
| BP2010 /EP6 | Appearance | A white or almost white crystalline powder | Conforms |
| Melting point | About 205°C | 206.4°C~206.7°C | |
| Identification | Meet the requirements | Conforms | |
| Appearance of solution | Clear, not more intense than Y7 | Conforms | |
| PH | 2.4~3.0 | 2.60 | |
| Loss on drying | ≤0.5% | 0.04% | |
| Sulphated ash | ≤0.1% | 0.01% | |
| Heavy metals | ≤20 ppm | <20 ppm | |
| Related substances | ≤0.25% | Conforms | |
| Assay | 99.0%~101.0% | 99.8% | |
| USP32 | Identification | Meet the requirements | Conforms |
| Loss on drying | ≤0.5% | 0.04% | |
| Residue on ignition | ≤0.1% | 0.01% | |
| Heavy metals | ≤0.003% | <0.003% | |
| Residue solvent - Ethanol | ≤0.5% | <0.04% | |
| Chloride | 16.9%~17.6% | 17.1% | |
| Assay | 98.0%~102.0% | 100.0% | |
| Conclusion: The product complies with BP2010/USP32/EP6 standard | |||
| Thiamine nitrate Basic information |
| Description References |
| Product Name: | Thiamine nitrate |
| Synonyms: | 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-thiazol-3-iumyl]ethanol;Thiaminenitratel;Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate(salt);vitaminb(sub1)nitrate;Thiamin Mononitrate;Thiaminenitrate,98%;Vitamin B1 Mono;Vitamine B1(mono) |
| CAS: | 532-43-4 |
| MF: | C12H17N5O4S |
| MW: | 327.36 |
| EINECS: | 208-537-4 |
| Product Categories: | Biochemistry;Vitamins;Vitamins and derivatives |
| Mol File: | 532-43-4.mol |
| Thiamine nitrate Chemical Properties |
| Melting point | 196-200°C |
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in metol. |
| form | solid |
| pka | 4.8(at 25ºC) |
| Merck | 14,9295 |
| BRN | 3857790 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | UIERGBJEBXXIGO-UHFFFAOYSA-N |
| CAS DataBase Reference | 532-43-4(CAS DataBase Reference) |
| EPA Substance Registry System | Thiamine nitrate (532-43-4) |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 1 |
| RTECS | XI7400000 |
| TSCA | Yes |
| HS Code | 29362200 |
| MSDS Information |
| Thiamine nitrate Usage And Synthesis |
| Description | Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations. Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour. |
| References | [1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995 [2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008 [3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369 |
| Chemical Properties | White or almost white, crystalline powder or small, colourless crystals. |
| Uses | Vitamin B1. |
| Safety Profile | Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES. |
