GMP Pharmaceutical Sodium Salicylate CAS 54-21-7

Min.Order: 1,000

Product origin: Hefei, Anhui, China

Infringement complaint:

Complaint

US$ 6 ~ 20

Description

Sodium Salicylate CAS 54-21-7

Name	Sodium salicylate
Synonyms	Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
Molecular Formula	C₇H₅NaO₃
Molecular Weight	160.10
CAS Registry Number	54-21-7
EINECS	200-198-0

Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin (sc-202471), sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK β. Sodium salicylate has been shown to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.

Function
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID),and induces apoptosis in cancer cells and also necrosis.It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.

Application
In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative.

Specification

Item	Index	Result
Appearance	White crystalline powder, soluble in water. It dissolves in dilute acid and alkaline solutions.	Conform
Identification	a) TLC results	Conform
	b) Color reaction with sulfuric acid	Conform
	c) Color reaction	Conform
Ph	4.5 to 7.0	6
Specific optical rotation	-203°to -216°°	-206°
Specific absorbance at 353nm	290 to 310	308
Specific absorbance at 353nm	290 to 310	308
Light-absorbing impurities	a) At 430nm not greater than 0.25	0.08
Light-absorbing impurities	b) At 490nm not greater than 0.20	0.01
Related substances	4-epioxytetracycline≤ 0.5%	0.20%
	Tetracycline hydrochloride≤2.0%	0.30%
	Peak on the tail of the main peak≤2.0%	1.60%
Heavy metals	Not more than 50ppm	<50ppm
Water	6.0 % to 9.0%	7.70%
Sulphated ash	Not more than 0.5%	0.03%
Assay	95.0% -100.5%(C22H24N2O9) based onanhydrous substance	99.10%